Signaling pathways involved in cardiogenesis

Deepak Srivastava, Chulan Kwon

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter gives an overview on signaling pathways involved in cardiogenesis and congenital heart disease (CHD) considering different regions of the developing heart. The transcription factor Tbx1, which appears to be a cause of cardiac and craniofacial disorders in humans, is a major transcriptional regulator of the serum response factor (SRF), and is necessary for proper development of conotruncal myocardium and fibroblast growth factor secretion. Islet1 (Isl1), a transcription factor involved in pancreatic development, is also necessary for its development. The Wnt signals play a dynamic and critical role in regulating cardiac progenitors. Wnt signals are necessary to promote mesoderm formation, but subsequently need to be repressed in order for cardiac mesoderm to emerge. A discrete dorsalventral (DV) polarity is present in the primitive heart tube in addition to the AP segmentation. Congenital cardiac defects involving the cardiac outflow tract, aortic arch, ductus arteriosus, and proximal pulmonary arteries account for 20-30 percent of all CHD. This region of the heart undergoes extensive and rather complex morphogenetic changes, with reciprocal interactions between neural crest cells and the second heart field (SHF) and endoderm playing critical roles. Disruption of SHF development by mutation of genes such as Tbx1, Fgf8, and Isl1 results in defects similar to those observed with neural crest disruption, including persistent truncus arteriosus, malalignment of the outflow tract of the heart with the ventricular chambers, and ventricular septal defects. SHF-derived myocardial cells neighbor neural crest-derived cells and secrete growth factors in a Tbx1-dependent manner. Such growth factors influence neural crest cells, and reciprocal interactions between the SHF and neural crest-derived cells in the outflow tract are likely essential for normal development of heart.

Original languageEnglish (US)
Title of host publicationHandbook of Cell Signaling, 2/e
PublisherElsevier Inc.
Pages2601-2609
Number of pages9
Volume3
ISBN (Print)9780123741455
DOIs
StatePublished - 2010
Externally publishedYes

Fingerprint

Neural Crest
Mesoderm
Heart Diseases
Intercellular Signaling Peptides and Proteins
Persistent Truncus Arteriosus
Transcription Factors
Defects
Serum Response Factor
Ductus Arteriosus
Endoderm
Fibroblast Growth Factors
Ventricular Heart Septal Defects
Thoracic Aorta
Cell Communication
Pulmonary Artery
Arches
Myocardium
Genes
Mutation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Srivastava, D., & Kwon, C. (2010). Signaling pathways involved in cardiogenesis. In Handbook of Cell Signaling, 2/e (Vol. 3, pp. 2601-2609). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-374145-5.00309-0

Signaling pathways involved in cardiogenesis. / Srivastava, Deepak; Kwon, Chulan.

Handbook of Cell Signaling, 2/e. Vol. 3 Elsevier Inc., 2010. p. 2601-2609.

Research output: Chapter in Book/Report/Conference proceedingChapter

Srivastava, D & Kwon, C 2010, Signaling pathways involved in cardiogenesis. in Handbook of Cell Signaling, 2/e. vol. 3, Elsevier Inc., pp. 2601-2609. https://doi.org/10.1016/B978-0-12-374145-5.00309-0
Srivastava D, Kwon C. Signaling pathways involved in cardiogenesis. In Handbook of Cell Signaling, 2/e. Vol. 3. Elsevier Inc. 2010. p. 2601-2609 https://doi.org/10.1016/B978-0-12-374145-5.00309-0
Srivastava, Deepak ; Kwon, Chulan. / Signaling pathways involved in cardiogenesis. Handbook of Cell Signaling, 2/e. Vol. 3 Elsevier Inc., 2010. pp. 2601-2609
@inbook{27523d6f19ee4534965cf24795e45c21,
title = "Signaling pathways involved in cardiogenesis",
abstract = "This chapter gives an overview on signaling pathways involved in cardiogenesis and congenital heart disease (CHD) considering different regions of the developing heart. The transcription factor Tbx1, which appears to be a cause of cardiac and craniofacial disorders in humans, is a major transcriptional regulator of the serum response factor (SRF), and is necessary for proper development of conotruncal myocardium and fibroblast growth factor secretion. Islet1 (Isl1), a transcription factor involved in pancreatic development, is also necessary for its development. The Wnt signals play a dynamic and critical role in regulating cardiac progenitors. Wnt signals are necessary to promote mesoderm formation, but subsequently need to be repressed in order for cardiac mesoderm to emerge. A discrete dorsalventral (DV) polarity is present in the primitive heart tube in addition to the AP segmentation. Congenital cardiac defects involving the cardiac outflow tract, aortic arch, ductus arteriosus, and proximal pulmonary arteries account for 20-30 percent of all CHD. This region of the heart undergoes extensive and rather complex morphogenetic changes, with reciprocal interactions between neural crest cells and the second heart field (SHF) and endoderm playing critical roles. Disruption of SHF development by mutation of genes such as Tbx1, Fgf8, and Isl1 results in defects similar to those observed with neural crest disruption, including persistent truncus arteriosus, malalignment of the outflow tract of the heart with the ventricular chambers, and ventricular septal defects. SHF-derived myocardial cells neighbor neural crest-derived cells and secrete growth factors in a Tbx1-dependent manner. Such growth factors influence neural crest cells, and reciprocal interactions between the SHF and neural crest-derived cells in the outflow tract are likely essential for normal development of heart.",
author = "Deepak Srivastava and Chulan Kwon",
year = "2010",
doi = "10.1016/B978-0-12-374145-5.00309-0",
language = "English (US)",
isbn = "9780123741455",
volume = "3",
pages = "2601--2609",
booktitle = "Handbook of Cell Signaling, 2/e",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Signaling pathways involved in cardiogenesis

AU - Srivastava, Deepak

AU - Kwon, Chulan

PY - 2010

Y1 - 2010

N2 - This chapter gives an overview on signaling pathways involved in cardiogenesis and congenital heart disease (CHD) considering different regions of the developing heart. The transcription factor Tbx1, which appears to be a cause of cardiac and craniofacial disorders in humans, is a major transcriptional regulator of the serum response factor (SRF), and is necessary for proper development of conotruncal myocardium and fibroblast growth factor secretion. Islet1 (Isl1), a transcription factor involved in pancreatic development, is also necessary for its development. The Wnt signals play a dynamic and critical role in regulating cardiac progenitors. Wnt signals are necessary to promote mesoderm formation, but subsequently need to be repressed in order for cardiac mesoderm to emerge. A discrete dorsalventral (DV) polarity is present in the primitive heart tube in addition to the AP segmentation. Congenital cardiac defects involving the cardiac outflow tract, aortic arch, ductus arteriosus, and proximal pulmonary arteries account for 20-30 percent of all CHD. This region of the heart undergoes extensive and rather complex morphogenetic changes, with reciprocal interactions between neural crest cells and the second heart field (SHF) and endoderm playing critical roles. Disruption of SHF development by mutation of genes such as Tbx1, Fgf8, and Isl1 results in defects similar to those observed with neural crest disruption, including persistent truncus arteriosus, malalignment of the outflow tract of the heart with the ventricular chambers, and ventricular septal defects. SHF-derived myocardial cells neighbor neural crest-derived cells and secrete growth factors in a Tbx1-dependent manner. Such growth factors influence neural crest cells, and reciprocal interactions between the SHF and neural crest-derived cells in the outflow tract are likely essential for normal development of heart.

AB - This chapter gives an overview on signaling pathways involved in cardiogenesis and congenital heart disease (CHD) considering different regions of the developing heart. The transcription factor Tbx1, which appears to be a cause of cardiac and craniofacial disorders in humans, is a major transcriptional regulator of the serum response factor (SRF), and is necessary for proper development of conotruncal myocardium and fibroblast growth factor secretion. Islet1 (Isl1), a transcription factor involved in pancreatic development, is also necessary for its development. The Wnt signals play a dynamic and critical role in regulating cardiac progenitors. Wnt signals are necessary to promote mesoderm formation, but subsequently need to be repressed in order for cardiac mesoderm to emerge. A discrete dorsalventral (DV) polarity is present in the primitive heart tube in addition to the AP segmentation. Congenital cardiac defects involving the cardiac outflow tract, aortic arch, ductus arteriosus, and proximal pulmonary arteries account for 20-30 percent of all CHD. This region of the heart undergoes extensive and rather complex morphogenetic changes, with reciprocal interactions between neural crest cells and the second heart field (SHF) and endoderm playing critical roles. Disruption of SHF development by mutation of genes such as Tbx1, Fgf8, and Isl1 results in defects similar to those observed with neural crest disruption, including persistent truncus arteriosus, malalignment of the outflow tract of the heart with the ventricular chambers, and ventricular septal defects. SHF-derived myocardial cells neighbor neural crest-derived cells and secrete growth factors in a Tbx1-dependent manner. Such growth factors influence neural crest cells, and reciprocal interactions between the SHF and neural crest-derived cells in the outflow tract are likely essential for normal development of heart.

UR - http://www.scopus.com/inward/record.url?scp=84882896479&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882896479&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-374145-5.00309-0

DO - 10.1016/B978-0-12-374145-5.00309-0

M3 - Chapter

AN - SCOPUS:84882896479

SN - 9780123741455

VL - 3

SP - 2601

EP - 2609

BT - Handbook of Cell Signaling, 2/e

PB - Elsevier Inc.

ER -