Signaling on the endocytic pathway

Peter S. McPherson, Brian K. Kay, Natasha K. Hussain

Research output: Contribution to journalReview articlepeer-review

Abstract

Ligand binding to receptor tyrosine kinases and G-protein-coupled receptors initiates signal transduction events and induces receptor endocytosis via clathrincoated pits and vesicles. While receptor-mediated endocytosis has been traditionally considered an effective mechanism to attenuate ligand-activated responses, more recent studies demonstrate that signaling continues on the endocytic pathway. In fact, certain signaling events, such as the activation of the extracellular signal-regulated kinases, appear to require endocytosis. Protein components of signal transduction cascades can assemble at clathrin coated pits and remain associated with endocytic vesicles following their dynamin-dependent release from the plasma membrane. Thus, endocytic vesicles can function as a signaling compartment distinct from the plasma membrane. These observations demonstrate that endocytosis plays an important role in the activation and propagation of signaling pathways.

Original languageEnglish (US)
Pages (from-to)375-384
Number of pages10
JournalTraffic
Volume2
Issue number6
DOIs
StatePublished - 2001

Keywords

  • Clathrin
  • Dynamin
  • EGF
  • ERK
  • Endocytosis
  • Intersectin
  • MAP kinase
  • NGF
  • Ras

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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