Abstract
Ligand binding to receptor tyrosine kinases and G-protein-coupled receptors initiates signal transduction events and induces receptor endocytosis via clathrincoated pits and vesicles. While receptor-mediated endocytosis has been traditionally considered an effective mechanism to attenuate ligand-activated responses, more recent studies demonstrate that signaling continues on the endocytic pathway. In fact, certain signaling events, such as the activation of the extracellular signal-regulated kinases, appear to require endocytosis. Protein components of signal transduction cascades can assemble at clathrin coated pits and remain associated with endocytic vesicles following their dynamin-dependent release from the plasma membrane. Thus, endocytic vesicles can function as a signaling compartment distinct from the plasma membrane. These observations demonstrate that endocytosis plays an important role in the activation and propagation of signaling pathways.
Original language | English (US) |
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Pages (from-to) | 375-384 |
Number of pages | 10 |
Journal | Traffic |
Volume | 2 |
Issue number | 6 |
DOIs | |
State | Published - 2001 |
Externally published | Yes |
Keywords
- Clathrin
- Dynamin
- EGF
- ERK
- Endocytosis
- Intersectin
- MAP kinase
- NGF
- Ras
ASJC Scopus subject areas
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology