Signaling of cytokines is important in regulation of GnRH neurons

Sheng Wu, Andrew Wolfe

Research output: Contribution to journalReview article

Abstract

Cytokines encompass a broad class of peptides that mediate signals in a broad range of physiological situations including inflammation, infection, and obesity. The cytokine receptor-associated tyrosine kinase, Jak2, is one of the most important proteins mediating cytokine signaling pathway activation. Recently, our group has demonstrated that Jak2 signaling in the gonadotropin-releasing hormone (GnRH) neuron plays a critical role in fertility in males and females, implicating cytokine activation of the neuron in GnRH neuronal development and function. To date, the specific cytokine(s) essential for activating Jak2 during neuroendocrine development are not known. In this article, we review the evidence for the role of several class 1 cytokines in regulating GnRH neuronal development, GnRH secretion, and GnRH expression.

Original languageEnglish (US)
Pages (from-to)119-125
Number of pages7
JournalMolecular Neurobiology
Volume45
Issue number1
DOIs
StatePublished - Feb 2012

Keywords

  • Cytokines
  • Fertility
  • GnRH
  • Jak2
  • Signaling

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience

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