Signaling mechanisms for chemotaxis

Yu Wang, Chun Lin Chen, Miho Iijima

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations


Cells recognize external chemical gradients and translate these environmental cues into amplified intracellular signaling that results in elongated cell shape, actin polymerization toward the leading edge, and movement along the gradient. Mechanisms underlying chemotaxis are conserved evolutionarily from Dictyostelium amoeba to mammalian neutrophils. Recent studies have uncovered several parallel intracellular signaling pathways that crosstalk in chemotaxing cells. Here, we review these signaling mechanisms in Dictyostelium discoideum.

Original languageEnglish (US)
Pages (from-to)495-502
Number of pages8
JournalDevelopment Growth and Differentiation
Issue number4
StatePublished - May 2011


  • Dictyostelium
  • Phospholipase A2
  • PtdIns(3,4,5)P3
  • Ras GTPase
  • Soluble guanylyl cyclase
  • TorC2

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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