Signaling mechanisms for chemotaxis

Yu Wang; Chun Lin Chen; Miho Iijima

doi:10.1111/j.1440-169X.2011.01265.x

Signaling mechanisms for chemotaxis

Yu Wang, Chun Lin Chen, Miho Iijima

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Cells recognize external chemical gradients and translate these environmental cues into amplified intracellular signaling that results in elongated cell shape, actin polymerization toward the leading edge, and movement along the gradient. Mechanisms underlying chemotaxis are conserved evolutionarily from Dictyostelium amoeba to mammalian neutrophils. Recent studies have uncovered several parallel intracellular signaling pathways that crosstalk in chemotaxing cells. Here, we review these signaling mechanisms in Dictyostelium discoideum.

Original language	English (US)
Pages (from-to)	495-502
Number of pages	8
Journal	Development Growth and Differentiation
Volume	53
Issue number	4
DOIs	https://doi.org/10.1111/j.1440-169X.2011.01265.x
State	Published - May 2011

Keywords

Dictyostelium
Phospholipase A2
PtdIns(3,4,5)P3
Ras GTPase
Soluble guanylyl cyclase
TorC2

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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10.1111/j.1440-169X.2011.01265.x

Cite this

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title = "Signaling mechanisms for chemotaxis",

abstract = "Cells recognize external chemical gradients and translate these environmental cues into amplified intracellular signaling that results in elongated cell shape, actin polymerization toward the leading edge, and movement along the gradient. Mechanisms underlying chemotaxis are conserved evolutionarily from Dictyostelium amoeba to mammalian neutrophils. Recent studies have uncovered several parallel intracellular signaling pathways that crosstalk in chemotaxing cells. Here, we review these signaling mechanisms in Dictyostelium discoideum.",

keywords = "Dictyostelium, Phospholipase A2, PtdIns(3,4,5)P3, Ras GTPase, Soluble guanylyl cyclase, TorC2",

author = "Yu Wang and Chen, {Chun Lin} and Miho Iijima",

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AU - Chen, Chun Lin

AU - Iijima, Miho

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AB - Cells recognize external chemical gradients and translate these environmental cues into amplified intracellular signaling that results in elongated cell shape, actin polymerization toward the leading edge, and movement along the gradient. Mechanisms underlying chemotaxis are conserved evolutionarily from Dictyostelium amoeba to mammalian neutrophils. Recent studies have uncovered several parallel intracellular signaling pathways that crosstalk in chemotaxing cells. Here, we review these signaling mechanisms in Dictyostelium discoideum.

KW - Dictyostelium

KW - Phospholipase A2

KW - PtdIns(3,4,5)P3

KW - Ras GTPase

KW - Soluble guanylyl cyclase

KW - TorC2

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JO - Development Growth and Differentiation

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Signaling mechanisms for chemotaxis

Abstract

Keywords

ASJC Scopus subject areas

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