Abstract
Cells recognize external chemical gradients and translate these environmental cues into amplified intracellular signaling that results in elongated cell shape, actin polymerization toward the leading edge, and movement along the gradient. Mechanisms underlying chemotaxis are conserved evolutionarily from Dictyostelium amoeba to mammalian neutrophils. Recent studies have uncovered several parallel intracellular signaling pathways that crosstalk in chemotaxing cells. Here, we review these signaling mechanisms in Dictyostelium discoideum.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 495-502 |
| Number of pages | 8 |
| Journal | Development Growth and Differentiation |
| Volume | 53 |
| Issue number | 4 |
| DOIs | |
| State | Published - May 2011 |
Keywords
- Dictyostelium
- Phospholipase A2
- PtdIns(3,4,5)P3
- Ras GTPase
- Soluble guanylyl cyclase
- TorC2
ASJC Scopus subject areas
- Developmental Biology
- Cell Biology