Signaling by S-nitrosylation in the heart

Elizabeth Murphy, Mark Kohr, Sara Menazza, Tiffany Nguyen, Alicia Evangelista, Junhui Sun, Charles Jr Steenbergen

Research output: Contribution to journalArticle

Abstract

Nitric oxide is a gaseous signaling molecule that is well-known for the Nobel prize-winning research that defined nitric oxide as a physiological regulator of blood pressure in the cardiovascular system. Nitric oxide can signal via the classical pathway involving activation of guanylyl cyclase or by a post-translational modification, referred to as S-nitrosylation (SNO) that can occur on cysteine residues of proteins. As proteins with cysteine residues are common, this allows for amplification of the nitric oxide signaling. This review will focus on the possible mechanisms through which SNO can alter protein function in cardiac cells, and the role of SNO occupancy in these mechanisms. The specific mechanisms that regulate protein SNO, including redox-dependent processes, will also be discussed. This article is part of a Special Issue entitled "Redox Signalling in the Cardiovascular System".

Original languageEnglish (US)
Pages (from-to)18-25
Number of pages8
JournalJournal of Molecular and Cellular Cardiology
Volume73
DOIs
StatePublished - 2014

Fingerprint

Nitric Oxide
Cardiovascular System
Oxidation-Reduction
Cysteine
Nobel Prize
Proteins
Guanylate Cyclase
Protein S
Post Translational Protein Processing
Blood Pressure
Research

Keywords

  • Cardioportection
  • Nitric oxide
  • Oxidation

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Signaling by S-nitrosylation in the heart. / Murphy, Elizabeth; Kohr, Mark; Menazza, Sara; Nguyen, Tiffany; Evangelista, Alicia; Sun, Junhui; Steenbergen, Charles Jr.

In: Journal of Molecular and Cellular Cardiology, Vol. 73, 2014, p. 18-25.

Research output: Contribution to journalArticle

Murphy, Elizabeth ; Kohr, Mark ; Menazza, Sara ; Nguyen, Tiffany ; Evangelista, Alicia ; Sun, Junhui ; Steenbergen, Charles Jr. / Signaling by S-nitrosylation in the heart. In: Journal of Molecular and Cellular Cardiology. 2014 ; Vol. 73. pp. 18-25.
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