Signal transduction underlying growth cone guidance by diffusible factors

Hong Jun Song, Mu Ming Poo

Research output: Contribution to journalArticlepeer-review

Abstract

Many diffusible axon guidance cues and their receptors have been identified recently. These cues are often found to be bifunctional, acting as attractants or repellents under different circumstances. Studies of cytoplasmic signaling mechanisms have led to the notion that the response of a growth cone to a particular guidance cue depends on the internal state of the neuron, which, in turn, is under the influence of other coincident signals received by the neuron. Furthermore, many diffusible guidance cues appear to share common cytoplasmic signaling pathways.

Original languageEnglish (US)
Pages (from-to)355-363
Number of pages9
JournalCurrent Opinion in Neurobiology
Volume9
Issue number3
DOIs
StatePublished - Jun 1999
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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