Signal transduction to hypoxia-inducible factor 1

Research output: Contribution to journalArticle

Abstract

Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that functions as a master regulator of O2 homeostasis. HIF-1 target genes encode proteins that increase O2 delivery and mediate adaptive responses to O2 deprivation. HIF-1 activity is regulated by the cellular O2 concentration and by the major growth factor-stimulated signal transduction pathways. In human cancer cells, both intratumoral hypoxia and genetic alterations affecting signal transduction pathways lead to increased HIF-1 activity, which promotes angiogenesis, metabolic adaptation, and other critical aspects of tumor progression.

Original languageEnglish (US)
Pages (from-to)993-998
Number of pages6
JournalBiochemical Pharmacology
Volume64
Issue number5-6
DOIs
StatePublished - Sep 1 2002

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Keywords

  • Growth factor
  • MAP kinase
  • Phosphatidylinositol 3-kinase
  • Prolyl hydroxylase
  • Receptor tyrosine kinase

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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