Signal transduction to hypoxia-inducible factor 1

Gregg L. Semenza

doi:10.1016/S0006-2952(02)01168-1

Signal transduction to hypoxia-inducible factor 1

Gregg L. Semenza

School of Medicine

Research output: Contribution to journal › Article › peer-review

703 Scopus citations

Abstract

Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that functions as a master regulator of O₂ homeostasis. HIF-1 target genes encode proteins that increase O₂ delivery and mediate adaptive responses to O₂ deprivation. HIF-1 activity is regulated by the cellular O₂ concentration and by the major growth factor-stimulated signal transduction pathways. In human cancer cells, both intratumoral hypoxia and genetic alterations affecting signal transduction pathways lead to increased HIF-1 activity, which promotes angiogenesis, metabolic adaptation, and other critical aspects of tumor progression.

Original language	English (US)
Pages (from-to)	993-998
Number of pages	6
Journal	Biochemical Pharmacology
Volume	64
Issue number	5-6
DOIs	https://doi.org/10.1016/S0006-2952(02)01168-1
State	Published - Sep 1 2002

Keywords

Growth factor
MAP kinase
Phosphatidylinositol 3-kinase
Prolyl hydroxylase
Receptor tyrosine kinase

ASJC Scopus subject areas

Biochemistry
Pharmacology

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10.1016/S0006-2952(02)01168-1

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title = "Signal transduction to hypoxia-inducible factor 1",

abstract = "Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that functions as a master regulator of O2 homeostasis. HIF-1 target genes encode proteins that increase O2 delivery and mediate adaptive responses to O2 deprivation. HIF-1 activity is regulated by the cellular O2 concentration and by the major growth factor-stimulated signal transduction pathways. In human cancer cells, both intratumoral hypoxia and genetic alterations affecting signal transduction pathways lead to increased HIF-1 activity, which promotes angiogenesis, metabolic adaptation, and other critical aspects of tumor progression.",

keywords = "Growth factor, MAP kinase, Phosphatidylinositol 3-kinase, Prolyl hydroxylase, Receptor tyrosine kinase",

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AB - Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that functions as a master regulator of O2 homeostasis. HIF-1 target genes encode proteins that increase O2 delivery and mediate adaptive responses to O2 deprivation. HIF-1 activity is regulated by the cellular O2 concentration and by the major growth factor-stimulated signal transduction pathways. In human cancer cells, both intratumoral hypoxia and genetic alterations affecting signal transduction pathways lead to increased HIF-1 activity, which promotes angiogenesis, metabolic adaptation, and other critical aspects of tumor progression.

KW - Growth factor

KW - MAP kinase

KW - Phosphatidylinositol 3-kinase

KW - Prolyl hydroxylase

KW - Receptor tyrosine kinase

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AN - SCOPUS:0036710591

SN - 0006-2952

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EP - 998

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

IS - 5-6

ER -

Signal transduction to hypoxia-inducible factor 1

Abstract

Keywords

ASJC Scopus subject areas

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