Signal transduction proteins in tumors from puerto rican and caucasian gastric adenocarcinoma patients: Expression differences with potential for specific targeted therapies

José Cangiano, Barbara A. Centeno, Christopher R. Garrett, William Cáceres, Ana De Jesus-Acosta, Ji Hyun Lee, Orestes Pavía, Richard Jove, Luis Báez, Daniel M. Sullivan, Carlos A. Muro-Cacho, Teresita Muñoz-Antonia

Research output: Contribution to journalArticle

Abstract

Overexpression of the HER2/NEU gene is associated with aggressive behavior and poor prognosis in breast cancer, making the Her2/neu protein a directed-therapy target. Tumors of two Puerto Rican (PR) patients overexpressed Her2/neu and resulting partial clinical responses motivated us to compare Her2/neu expression in PR (n = 101) and Caucasian non-Hispanic (n = 95) patients. Immunohistochemistry of tumors showed overexpression of p-Stat3, Cyclin D1, and Her2/neu, compared to non-neoplastic mucosa. Her2/neu and EGF-R protein levels were statistically significantly different with higher levels of both proteins in the PR group. Importantly, Her2/neu expression was strong and diffuse in tumors with signet-ring morphology, while other histo-pathological subtypes showed higher intra-tumoral Her2/neu heterogeneity than typically observed in breast cancer. Targeted therapies in gastric cancer directed at EGF-R and Hers-2/neu pathways warrant further investigation. These therapies may be especially effective in PR patients and in patients with signet-ring cell morphologies with a dismal prognosis.

Original languageEnglish (US)
Pages (from-to)2090-2100
Number of pages11
JournalDigestive Diseases and Sciences
Volume53
Issue number8
DOIs
StatePublished - Aug 2008
Externally publishedYes

Fingerprint

Signal Transduction
Stomach
Adenocarcinoma
Hispanic Americans
Epidermal Growth Factor
Neoplasms
Proteins
Breast Neoplasms
erbB-2 Genes
Cyclin D1
Therapeutics
Stomach Neoplasms
Mucous Membrane
Immunohistochemistry

Keywords

  • Cyclin D1
  • Epidermal growth factor receptor
  • Gastric adenocarcinoma
  • Her2/neu
  • Stat3
  • Stomach cancer

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Signal transduction proteins in tumors from puerto rican and caucasian gastric adenocarcinoma patients : Expression differences with potential for specific targeted therapies. / Cangiano, José; Centeno, Barbara A.; Garrett, Christopher R.; Cáceres, William; De Jesus-Acosta, Ana; Lee, Ji Hyun; Pavía, Orestes; Jove, Richard; Báez, Luis; Sullivan, Daniel M.; Muro-Cacho, Carlos A.; Muñoz-Antonia, Teresita.

In: Digestive Diseases and Sciences, Vol. 53, No. 8, 08.2008, p. 2090-2100.

Research output: Contribution to journalArticle

Cangiano, J, Centeno, BA, Garrett, CR, Cáceres, W, De Jesus-Acosta, A, Lee, JH, Pavía, O, Jove, R, Báez, L, Sullivan, DM, Muro-Cacho, CA & Muñoz-Antonia, T 2008, 'Signal transduction proteins in tumors from puerto rican and caucasian gastric adenocarcinoma patients: Expression differences with potential for specific targeted therapies', Digestive Diseases and Sciences, vol. 53, no. 8, pp. 2090-2100. https://doi.org/10.1007/s10620-007-0118-5
Cangiano, José ; Centeno, Barbara A. ; Garrett, Christopher R. ; Cáceres, William ; De Jesus-Acosta, Ana ; Lee, Ji Hyun ; Pavía, Orestes ; Jove, Richard ; Báez, Luis ; Sullivan, Daniel M. ; Muro-Cacho, Carlos A. ; Muñoz-Antonia, Teresita. / Signal transduction proteins in tumors from puerto rican and caucasian gastric adenocarcinoma patients : Expression differences with potential for specific targeted therapies. In: Digestive Diseases and Sciences. 2008 ; Vol. 53, No. 8. pp. 2090-2100.
@article{3464b443f84f4bd38fae42b1431d4969,
title = "Signal transduction proteins in tumors from puerto rican and caucasian gastric adenocarcinoma patients: Expression differences with potential for specific targeted therapies",
abstract = "Overexpression of the HER2/NEU gene is associated with aggressive behavior and poor prognosis in breast cancer, making the Her2/neu protein a directed-therapy target. Tumors of two Puerto Rican (PR) patients overexpressed Her2/neu and resulting partial clinical responses motivated us to compare Her2/neu expression in PR (n = 101) and Caucasian non-Hispanic (n = 95) patients. Immunohistochemistry of tumors showed overexpression of p-Stat3, Cyclin D1, and Her2/neu, compared to non-neoplastic mucosa. Her2/neu and EGF-R protein levels were statistically significantly different with higher levels of both proteins in the PR group. Importantly, Her2/neu expression was strong and diffuse in tumors with signet-ring morphology, while other histo-pathological subtypes showed higher intra-tumoral Her2/neu heterogeneity than typically observed in breast cancer. Targeted therapies in gastric cancer directed at EGF-R and Hers-2/neu pathways warrant further investigation. These therapies may be especially effective in PR patients and in patients with signet-ring cell morphologies with a dismal prognosis.",
keywords = "Cyclin D1, Epidermal growth factor receptor, Gastric adenocarcinoma, Her2/neu, Stat3, Stomach cancer",
author = "Jos{\'e} Cangiano and Centeno, {Barbara A.} and Garrett, {Christopher R.} and William C{\'a}ceres and {De Jesus-Acosta}, Ana and Lee, {Ji Hyun} and Orestes Pav{\'i}a and Richard Jove and Luis B{\'a}ez and Sullivan, {Daniel M.} and Muro-Cacho, {Carlos A.} and Teresita Mu{\~n}oz-Antonia",
year = "2008",
month = "8",
doi = "10.1007/s10620-007-0118-5",
language = "English (US)",
volume = "53",
pages = "2090--2100",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Plenum Publishers",
number = "8",

}

TY - JOUR

T1 - Signal transduction proteins in tumors from puerto rican and caucasian gastric adenocarcinoma patients

T2 - Expression differences with potential for specific targeted therapies

AU - Cangiano, José

AU - Centeno, Barbara A.

AU - Garrett, Christopher R.

AU - Cáceres, William

AU - De Jesus-Acosta, Ana

AU - Lee, Ji Hyun

AU - Pavía, Orestes

AU - Jove, Richard

AU - Báez, Luis

AU - Sullivan, Daniel M.

AU - Muro-Cacho, Carlos A.

AU - Muñoz-Antonia, Teresita

PY - 2008/8

Y1 - 2008/8

N2 - Overexpression of the HER2/NEU gene is associated with aggressive behavior and poor prognosis in breast cancer, making the Her2/neu protein a directed-therapy target. Tumors of two Puerto Rican (PR) patients overexpressed Her2/neu and resulting partial clinical responses motivated us to compare Her2/neu expression in PR (n = 101) and Caucasian non-Hispanic (n = 95) patients. Immunohistochemistry of tumors showed overexpression of p-Stat3, Cyclin D1, and Her2/neu, compared to non-neoplastic mucosa. Her2/neu and EGF-R protein levels were statistically significantly different with higher levels of both proteins in the PR group. Importantly, Her2/neu expression was strong and diffuse in tumors with signet-ring morphology, while other histo-pathological subtypes showed higher intra-tumoral Her2/neu heterogeneity than typically observed in breast cancer. Targeted therapies in gastric cancer directed at EGF-R and Hers-2/neu pathways warrant further investigation. These therapies may be especially effective in PR patients and in patients with signet-ring cell morphologies with a dismal prognosis.

AB - Overexpression of the HER2/NEU gene is associated with aggressive behavior and poor prognosis in breast cancer, making the Her2/neu protein a directed-therapy target. Tumors of two Puerto Rican (PR) patients overexpressed Her2/neu and resulting partial clinical responses motivated us to compare Her2/neu expression in PR (n = 101) and Caucasian non-Hispanic (n = 95) patients. Immunohistochemistry of tumors showed overexpression of p-Stat3, Cyclin D1, and Her2/neu, compared to non-neoplastic mucosa. Her2/neu and EGF-R protein levels were statistically significantly different with higher levels of both proteins in the PR group. Importantly, Her2/neu expression was strong and diffuse in tumors with signet-ring morphology, while other histo-pathological subtypes showed higher intra-tumoral Her2/neu heterogeneity than typically observed in breast cancer. Targeted therapies in gastric cancer directed at EGF-R and Hers-2/neu pathways warrant further investigation. These therapies may be especially effective in PR patients and in patients with signet-ring cell morphologies with a dismal prognosis.

KW - Cyclin D1

KW - Epidermal growth factor receptor

KW - Gastric adenocarcinoma

KW - Her2/neu

KW - Stat3

KW - Stomach cancer

UR - http://www.scopus.com/inward/record.url?scp=46449087606&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=46449087606&partnerID=8YFLogxK

U2 - 10.1007/s10620-007-0118-5

DO - 10.1007/s10620-007-0118-5

M3 - Article

C2 - 18224443

AN - SCOPUS:46449087606

VL - 53

SP - 2090

EP - 2100

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 8

ER -