Signal transduction proteins in tumors from puerto rican and caucasian gastric adenocarcinoma patients: Expression differences with potential for specific targeted therapies

José Cangiano, Barbara A. Centeno, Christopher R. Garrett, William Cáceres, Ana De Jesús, Ji Hyun Lee, Orestes Pavía, Richard Jove, Luis Báez, Daniel M. Sullivan, Carlos A. Muro-Cacho, Teresita Muñoz-Antonia

Research output: Contribution to journalArticlepeer-review

Abstract

Overexpression of the HER2/NEU gene is associated with aggressive behavior and poor prognosis in breast cancer, making the Her2/neu protein a directed-therapy target. Tumors of two Puerto Rican (PR) patients overexpressed Her2/neu and resulting partial clinical responses motivated us to compare Her2/neu expression in PR (n = 101) and Caucasian non-Hispanic (n = 95) patients. Immunohistochemistry of tumors showed overexpression of p-Stat3, Cyclin D1, and Her2/neu, compared to non-neoplastic mucosa. Her2/neu and EGF-R protein levels were statistically significantly different with higher levels of both proteins in the PR group. Importantly, Her2/neu expression was strong and diffuse in tumors with signet-ring morphology, while other histo-pathological subtypes showed higher intra-tumoral Her2/neu heterogeneity than typically observed in breast cancer. Targeted therapies in gastric cancer directed at EGF-R and Hers-2/neu pathways warrant further investigation. These therapies may be especially effective in PR patients and in patients with signet-ring cell morphologies with a dismal prognosis.

Original languageEnglish (US)
Pages (from-to)2090-2100
Number of pages11
JournalDigestive Diseases and Sciences
Volume53
Issue number8
DOIs
StatePublished - Aug 1 2008
Externally publishedYes

Keywords

  • Cyclin D1
  • Epidermal growth factor receptor
  • Gastric adenocarcinoma
  • Her2/neu
  • Stat3
  • Stomach cancer

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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