TY - JOUR
T1 - Signal transduction pathways to apoptosis
AU - McConkey, David J.
AU - Orrenius, Sten
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1994/10
Y1 - 1994/10
N2 - Recent work has demonstrated that a number of signalling events, including cytosolic Ca2+ rises, cAMP accumulation, activation of protein kinase C, activation of protein tyrosine kinases, and production of ceramide, regulate apoptosis in diverse model systems. However, in some cells these signals promote apoptosis, whereas in others they block the response. This review discusses these observations and proposes explanations for how a given set of signal transduction systems might be involved in multiple cellular responses.
AB - Recent work has demonstrated that a number of signalling events, including cytosolic Ca2+ rises, cAMP accumulation, activation of protein kinase C, activation of protein tyrosine kinases, and production of ceramide, regulate apoptosis in diverse model systems. However, in some cells these signals promote apoptosis, whereas in others they block the response. This review discusses these observations and proposes explanations for how a given set of signal transduction systems might be involved in multiple cellular responses.
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U2 - 10.1016/0962-8924(94)90087-6
DO - 10.1016/0962-8924(94)90087-6
M3 - Review article
C2 - 14731626
AN - SCOPUS:0027934664
SN - 0962-8924
VL - 4
SP - 370
EP - 375
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 10
ER -