Signal transduction pathways to apoptosis

David J. McConkey, Sten Orrenius

Research output: Contribution to journalReview articlepeer-review

156 Scopus citations


Recent work has demonstrated that a number of signalling events, including cytosolic Ca2+ rises, cAMP accumulation, activation of protein kinase C, activation of protein tyrosine kinases, and production of ceramide, regulate apoptosis in diverse model systems. However, in some cells these signals promote apoptosis, whereas in others they block the response. This review discusses these observations and proposes explanations for how a given set of signal transduction systems might be involved in multiple cellular responses.

Original languageEnglish (US)
Pages (from-to)370-375
Number of pages6
JournalTrends in Cell Biology
Issue number10
StatePublished - Oct 1994
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


Dive into the research topics of 'Signal transduction pathways to apoptosis'. Together they form a unique fingerprint.

Cite this