Signal transduction by reactive oxygen species in non-phagocytic cells

Toren Finkel

Research output: Contribution to journalArticle

Abstract

A growing body of evidence suggests a potential role for oxygen-derived radicals such as superoxide anions and hydrogen peroxide as intracellular signaling molecules. Recently, progress has been made regarding the regulation of oxidant production in non-phagocytic cells. Significant gaps in understanding persist, however, especially in regard to the source(s) of oxidant production and the direct intracellular target(s) of oxygen radicals. Nonetheless, numerous recent studies have implicated a dynamic change in the intracellular redox state as an important determinant in a host of cellular decisions ranging from growth, to apoptosis, to cellular senescence.

Original languageEnglish (US)
Pages (from-to)337-340
Number of pages4
JournalJournal of Leukocyte Biology
Volume65
Issue number3
StatePublished - 1999
Externally publishedYes

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Oxidants
Reactive Oxygen Species
Signal Transduction
Cell Aging
Superoxides
Hydrogen Peroxide
Oxidation-Reduction
Apoptosis
Growth

Keywords

  • Apoptosis
  • NADPH oxidase
  • p53
  • rac
  • ras

ASJC Scopus subject areas

  • Cell Biology

Cite this

Signal transduction by reactive oxygen species in non-phagocytic cells. / Finkel, Toren.

In: Journal of Leukocyte Biology, Vol. 65, No. 3, 1999, p. 337-340.

Research output: Contribution to journalArticle

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