Abstract
The production of mitochondrial reactive oxygen species occurs as a consequence of aerobic metabolism. Mitochondrial oxidants are increasingly viewed less as byproducts of metabolism and more as important signaling molecules. Here, I review several notable examples, including the cellular response to hypoxia, aspects of innate immunity, the regulation of autophagy, and stem cell self-renewal capacity, where evidence suggests an important regulatory role for mitochondrial oxidants.
Original language | English (US) |
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Pages (from-to) | 4434-4440 |
Number of pages | 7 |
Journal | Journal of Biological Chemistry |
Volume | 287 |
Issue number | 7 |
DOIs | |
State | Published - Feb 10 2012 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology