Signal transduction by mitochondrial oxidants

Toren Finkel

Research output: Contribution to journalArticlepeer-review

240 Scopus citations


The production of mitochondrial reactive oxygen species occurs as a consequence of aerobic metabolism. Mitochondrial oxidants are increasingly viewed less as byproducts of metabolism and more as important signaling molecules. Here, I review several notable examples, including the cellular response to hypoxia, aspects of innate immunity, the regulation of autophagy, and stem cell self-renewal capacity, where evidence suggests an important regulatory role for mitochondrial oxidants.

Original languageEnglish (US)
Pages (from-to)4434-4440
Number of pages7
JournalJournal of Biological Chemistry
Issue number7
StatePublished - Feb 10 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology


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