Abstract
Human herpesvirus 8 (HHV-8) viral interieukin-6 (vIL-6) mediates signaling through the gp130 signal transducer but unlike human IL-6 (hIL-6) does not require the nonsignaling gp80 α subunit of the IL-6 receptor complex. By utilizing a gp80-refractory vIL-6 variant, vIL-6(R189L), we found that signal transduction, as measured by STAT1 and STAT3 activation and gp130 tyrosine phosphorylation in gp80+/gp130+ HEK293T cells, was modulated by gp80. Furthermore, the signaling and BAF-130 cell growth-promoting activities of vIL-6 and hIL-6 could be distinguished, and exogenous addition of soluble gp80 enhanced cell growth supported by vIL-6. Our findings demonstrate that gp80 can modulate vIL-6 activity and that vIL-6 and hIL-6 signaling are not directly equivalent.
Original language | English (US) |
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Pages (from-to) | 10874-10878 |
Number of pages | 5 |
Journal | Journal of virology |
Volume | 80 |
Issue number | 21 |
DOIs | |
State | Published - Nov 2006 |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology