Signal-to-noise ratio analysis and improvement for fluorescence tomography imaging

Huiquan Wang, Xing Feng, Boya Shi, Wenxuan Liang, Yongping Chen, Jinhai Wang, Xingde Li

Research output: Contribution to journalArticlepeer-review

Abstract

CCD-based fluorescence tomography is widely used for small animal whole-body imaging. In this report, systematic signal-to-noise ratio (SNR) analyses of a fluorescence tomography imaging (FTI) system were performed, resulting in an easy-to-follow strategy to optimize hardware configurations and operational conditions for acquiring high-quality imaging data and for improving the overall system performance. Phantom experiments were conducted to demonstrate the performance improvement by these optimizations. The improved performance was further verified by imaging a tumor-bearing mouse in vivo. This report provides general and practical guidelines for setting up a high-performance electron multiplying charge coupled device based FTI system to achieve an optimized SNR, which can be useful for future FTI technology development.

Original languageEnglish (US)
Article number093114
JournalReview of Scientific Instruments
Volume89
Issue number9
DOIs
StatePublished - Sep 1 2018

ASJC Scopus subject areas

  • Instrumentation

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