Sigma opioid receptor; SKF-10,047 update

N. Khazan, G. A. Young, E. E. El-Fakahany, O. Hong, D. Calligaro

Research output: Contribution to journalArticle

Abstract

We found that (-)-SKF-10,047 blocks EEG and behavioral effects of morphine in the naive rat, precipitates withdrawal in morphine-dependent rats, produces physical dependence as evidenced by naloxone-induced withdrawal, and displaces [3H] dihydromorphine from brain homogenates. (+)-SKF- 10,047 did not produce dependence upon chronic treatment, and it did not displace [3H] dihydromorphine from brain homogenates. Such pharmacodynamic dissociation of SKF-10,047 effects suggests an association of sigma receptors with psychotogenic, but not opioid characteristics. The latter are most likely mediated by mu or kappa receptors.

Original languageEnglish (US)
Pages (from-to)339-340
Number of pages2
JournalNeuropeptides
Volume5
Issue number4-6
DOIs
StatePublished - Feb 1985

ASJC Scopus subject areas

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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    Khazan, N., Young, G. A., El-Fakahany, E. E., Hong, O., & Calligaro, D. (1985). Sigma opioid receptor; SKF-10,047 update. Neuropeptides, 5(4-6), 339-340. https://doi.org/10.1016/0143-4179(85)90022-8