Side-effect profile of brimonidine tartrate in children

Sami Al-Shahwan, Abdullah A. Al-Torbak, Shahira Turkmani, Mamdouh Al-Omran, Ibrahim Al-Jadaan, Deepak P. Edward

Research output: Contribution to journalArticle

Abstract

Purpose: To investigate brimonidine-related side effects and the efficacy of brimonidine in lowering intraocular pressure (IOP) in children with primary infantile and secondary glaucoma. Study Design: Single-center, prospective, interventional, noncomparative case series. Participants: Eighty-three children (mean age, 7.84 years) met the inclusion criteria. Methods: Medical records were reviewed to identify children with primary infantile or other forms of secondary pediatric glaucoma from birth to 15 years who received brimonidine as adjunctive therapy for glaucoma. The parents of the children who met the inclusion criteria completed a detailed questionnaire-based interview. The children were examined to assess weight, major systemic effects, and efficacy of adjunctive brimonidine therapy. Main Outcome Measures: Questionnaire-based interview of parents to assess side effects of brimonidine and IOP-lowering effect of adjunctive brimonidine. Results: Parents reported symptoms in 70 of 83 children (84%). The most common side effects were excessive sleepiness and lethargy (76%), eye itching and rubbing (49%), and stinging and burning of the eyes (39%). Logistic regression analysis showed a statistically significant independent association between age and weight with lethargy and sleepiness. In symptomatic patients, symptoms' frequency increased with low weight (

Original languageEnglish (US)
JournalOphthalmology
Volume112
Issue number12
DOIs
StatePublished - Dec 2005
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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    Al-Shahwan, S., Al-Torbak, A. A., Turkmani, S., Al-Omran, M., Al-Jadaan, I., & Edward, D. P. (2005). Side-effect profile of brimonidine tartrate in children. Ophthalmology, 112(12). https://doi.org/10.1016/j.ophtha.2005.06.035