Abstract
Injection of sickle cell erythrocytes (SS, SC, Sthal, and AS) into the anterior chambers of living human, monkey, and guinea pig eyes resulted in conversion of erythrocyte to the sickled configuration. Immune responses did not appear to play an important role in influencing this phenomenon. The number of cells sickled was directly related to the concentration of hemoglobin S. In human and monkey eyes, the severity of elevated IOP appeared to be related to the type of cells injected and their concentration of hemoglobin S. Even the ordinarily benign genotype of sickle cell trait demonstrated sickling in the anterior chamber and elevation of the IOP.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 32-51 |
| Number of pages | 20 |
| Journal | Ophthalmic Surgery |
| Volume | 10 |
| Issue number | 4 |
| State | Published - 1979 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Ophthalmology
Cite this
Sickled erythrocytes, hyphema, and secondary glaucoma. II. Injected sickle cell erythrocytes into human, monkey, and guinea pig anterior chambers. The induction of sickling and secondary glaucoma. / Goldberg, Morton F; Dizon, R.; Raichand, M.
In: Ophthalmic Surgery, Vol. 10, No. 4, 1979, p. 32-51.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sickled erythrocytes, hyphema, and secondary glaucoma. II. Injected sickle cell erythrocytes into human, monkey, and guinea pig anterior chambers. The induction of sickling and secondary glaucoma
AU - Goldberg, Morton F
AU - Dizon, R.
AU - Raichand, M.
PY - 1979
Y1 - 1979
N2 - Injection of sickle cell erythrocytes (SS, SC, Sthal, and AS) into the anterior chambers of living human, monkey, and guinea pig eyes resulted in conversion of erythrocyte to the sickled configuration. Immune responses did not appear to play an important role in influencing this phenomenon. The number of cells sickled was directly related to the concentration of hemoglobin S. In human and monkey eyes, the severity of elevated IOP appeared to be related to the type of cells injected and their concentration of hemoglobin S. Even the ordinarily benign genotype of sickle cell trait demonstrated sickling in the anterior chamber and elevation of the IOP.
AB - Injection of sickle cell erythrocytes (SS, SC, Sthal, and AS) into the anterior chambers of living human, monkey, and guinea pig eyes resulted in conversion of erythrocyte to the sickled configuration. Immune responses did not appear to play an important role in influencing this phenomenon. The number of cells sickled was directly related to the concentration of hemoglobin S. In human and monkey eyes, the severity of elevated IOP appeared to be related to the type of cells injected and their concentration of hemoglobin S. Even the ordinarily benign genotype of sickle cell trait demonstrated sickling in the anterior chamber and elevation of the IOP.
UR - http://www.scopus.com/inward/record.url?scp=0018774467&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018774467&partnerID=8YFLogxK
M3 - Article
C2 - 111202
AN - SCOPUS:0018774467
VL - 10
SP - 32
EP - 51
JO - Ophthalmic Surgery Lasers and Imaging Retina
JF - Ophthalmic Surgery Lasers and Imaging Retina
SN - 2325-8160
IS - 4
ER -