TY - CHAP
T1 - Sickle cell retinopathy and hemoglobinopathies
AU - Lutty, Gerard A.
AU - Van Meurs, Jan
AU - Bird, Alan C.
AU - Downes, Susan M.
PY - 2007
Y1 - 2007
N2 - Sickle cell hemoglobinopathies all share the common feature of an abnormal globin chain, which leads to sickling of erythrocytes and obstruction of the microcirculation. Sickle vaso-occlusive events are insidious and affect virtually every vascular bed in the eye, often with visually devastating consequences. Vaso-occlusion most profoundly affects the retina, the light-sensitive tissue that lines the inside wall of the posterior aspect of the eye, because it is exquisitely sensitive to deprivation of oxygen. Even temporary vaso-occlusion, if longer than about 1.5-2 h, can result in permanent infarction of the retina. Most, if not all, of the complications of sickle cell disease in retina originate from the vaso-occlusive processes. The pathological changes can be divided into nonproliferative and proliferative events.
AB - Sickle cell hemoglobinopathies all share the common feature of an abnormal globin chain, which leads to sickling of erythrocytes and obstruction of the microcirculation. Sickle vaso-occlusive events are insidious and affect virtually every vascular bed in the eye, often with visually devastating consequences. Vaso-occlusion most profoundly affects the retina, the light-sensitive tissue that lines the inside wall of the posterior aspect of the eye, because it is exquisitely sensitive to deprivation of oxygen. Even temporary vaso-occlusion, if longer than about 1.5-2 h, can result in permanent infarction of the retina. Most, if not all, of the complications of sickle cell disease in retina originate from the vaso-occlusive processes. The pathological changes can be divided into nonproliferative and proliferative events.
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U2 - 10.1007/978-3-540-29542-6_27
DO - 10.1007/978-3-540-29542-6_27
M3 - Chapter
AN - SCOPUS:84892079517
SN - 9783540295419
SP - 700
EP - 734
BT - Retinal Vascular Disease
PB - Springer Berlin Heidelberg
ER -