Sickle cell retinopathy and hemoglobinopathies

Gerard Anthony Lutty, Jan Van Meurs, Alan C. Bird, Susan M. Downes

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Sickle cell hemoglobinopathies all share the common feature of an abnormal globin chain, which leads to sickling of erythrocytes and obstruction of the microcirculation. Sickle vaso-occlusive events are insidious and affect virtually every vascular bed in the eye, often with visually devastating consequences. Vaso-occlusion most profoundly affects the retina, the light-sensitive tissue that lines the inside wall of the posterior aspect of the eye, because it is exquisitely sensitive to deprivation of oxygen. Even temporary vaso-occlusion, if longer than about 1.5-2 h, can result in permanent infarction of the retina. Most, if not all, of the complications of sickle cell disease in retina originate from the vaso-occlusive processes. The pathological changes can be divided into nonproliferative and proliferative events.

Original languageEnglish (US)
Title of host publicationRetinal Vascular Disease
PublisherSpringer Berlin Heidelberg
Pages700-734
Number of pages35
ISBN (Print)9783540295419
DOIs
StatePublished - 2007

Fingerprint

Hemoglobinopathies
Retina
Globins
Sickle Cell Anemia
Microcirculation
Infarction
Blood Vessels
Erythrocytes
Oxygen
Light

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lutty, G. A., Van Meurs, J., Bird, A. C., & Downes, S. M. (2007). Sickle cell retinopathy and hemoglobinopathies. In Retinal Vascular Disease (pp. 700-734). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-540-29542-6_27

Sickle cell retinopathy and hemoglobinopathies. / Lutty, Gerard Anthony; Van Meurs, Jan; Bird, Alan C.; Downes, Susan M.

Retinal Vascular Disease. Springer Berlin Heidelberg, 2007. p. 700-734.

Research output: Chapter in Book/Report/Conference proceedingChapter

Lutty, GA, Van Meurs, J, Bird, AC & Downes, SM 2007, Sickle cell retinopathy and hemoglobinopathies. in Retinal Vascular Disease. Springer Berlin Heidelberg, pp. 700-734. https://doi.org/10.1007/978-3-540-29542-6_27
Lutty GA, Van Meurs J, Bird AC, Downes SM. Sickle cell retinopathy and hemoglobinopathies. In Retinal Vascular Disease. Springer Berlin Heidelberg. 2007. p. 700-734 https://doi.org/10.1007/978-3-540-29542-6_27
Lutty, Gerard Anthony ; Van Meurs, Jan ; Bird, Alan C. ; Downes, Susan M. / Sickle cell retinopathy and hemoglobinopathies. Retinal Vascular Disease. Springer Berlin Heidelberg, 2007. pp. 700-734
@inbook{a8f5ad9a7192446596d62de1656d3969,
title = "Sickle cell retinopathy and hemoglobinopathies",
abstract = "Sickle cell hemoglobinopathies all share the common feature of an abnormal globin chain, which leads to sickling of erythrocytes and obstruction of the microcirculation. Sickle vaso-occlusive events are insidious and affect virtually every vascular bed in the eye, often with visually devastating consequences. Vaso-occlusion most profoundly affects the retina, the light-sensitive tissue that lines the inside wall of the posterior aspect of the eye, because it is exquisitely sensitive to deprivation of oxygen. Even temporary vaso-occlusion, if longer than about 1.5-2 h, can result in permanent infarction of the retina. Most, if not all, of the complications of sickle cell disease in retina originate from the vaso-occlusive processes. The pathological changes can be divided into nonproliferative and proliferative events.",
author = "Lutty, {Gerard Anthony} and {Van Meurs}, Jan and Bird, {Alan C.} and Downes, {Susan M.}",
year = "2007",
doi = "10.1007/978-3-540-29542-6_27",
language = "English (US)",
isbn = "9783540295419",
pages = "700--734",
booktitle = "Retinal Vascular Disease",
publisher = "Springer Berlin Heidelberg",

}

TY - CHAP

T1 - Sickle cell retinopathy and hemoglobinopathies

AU - Lutty, Gerard Anthony

AU - Van Meurs, Jan

AU - Bird, Alan C.

AU - Downes, Susan M.

PY - 2007

Y1 - 2007

N2 - Sickle cell hemoglobinopathies all share the common feature of an abnormal globin chain, which leads to sickling of erythrocytes and obstruction of the microcirculation. Sickle vaso-occlusive events are insidious and affect virtually every vascular bed in the eye, often with visually devastating consequences. Vaso-occlusion most profoundly affects the retina, the light-sensitive tissue that lines the inside wall of the posterior aspect of the eye, because it is exquisitely sensitive to deprivation of oxygen. Even temporary vaso-occlusion, if longer than about 1.5-2 h, can result in permanent infarction of the retina. Most, if not all, of the complications of sickle cell disease in retina originate from the vaso-occlusive processes. The pathological changes can be divided into nonproliferative and proliferative events.

AB - Sickle cell hemoglobinopathies all share the common feature of an abnormal globin chain, which leads to sickling of erythrocytes and obstruction of the microcirculation. Sickle vaso-occlusive events are insidious and affect virtually every vascular bed in the eye, often with visually devastating consequences. Vaso-occlusion most profoundly affects the retina, the light-sensitive tissue that lines the inside wall of the posterior aspect of the eye, because it is exquisitely sensitive to deprivation of oxygen. Even temporary vaso-occlusion, if longer than about 1.5-2 h, can result in permanent infarction of the retina. Most, if not all, of the complications of sickle cell disease in retina originate from the vaso-occlusive processes. The pathological changes can be divided into nonproliferative and proliferative events.

UR - http://www.scopus.com/inward/record.url?scp=84892079517&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84892079517&partnerID=8YFLogxK

U2 - 10.1007/978-3-540-29542-6_27

DO - 10.1007/978-3-540-29542-6_27

M3 - Chapter

AN - SCOPUS:84892079517

SN - 9783540295419

SP - 700

EP - 734

BT - Retinal Vascular Disease

PB - Springer Berlin Heidelberg

ER -