Sialomes and Mialomes: A Systems-Biology View of Tick Tissues and Tick-Host Interactions

Jindřich Chmelař, Jan Kotál, Shahid Karim, Petr Kopacek, Ivo M.B. Francischetti, Joao H.F. Pedra, Michail Kotsyfakis

Research output: Contribution to journalReview articlepeer-review

Abstract

Tick saliva facilitates tick feeding and infection of the host. Gene expression analysis of tick salivary glands and other tissues involved in host-pathogen interactions has revealed a wide range of bioactive tick proteins. Transcriptomic analysis has been a milestone in the field and has recently been enhanced by next-generation sequencing (NGS). Furthermore, the application of quantitative proteomics to ticks with unknown genomes has provided deeper insights into the molecular mechanisms underlying tick hematophagy, pathogen transmission, and tick-host-pathogen interactions. We review current knowledge on the transcriptomics and proteomics of tick tissues from a systems-biology perspective and discuss future challenges in the field.

Original languageEnglish (US)
Pages (from-to)242-254
Number of pages13
JournalTrends in parasitology
Volume32
Issue number3
DOIs
StatePublished - Mar 1 2016
Externally publishedYes

Keywords

  • Next-generation sequencing
  • Sialomes
  • Systems biology
  • Tick-borne pathogens

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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