Sialic acids on the plasma membrane of cultured human lymphoid cells: Chemical aspects and biosynthesis

Steven A. Rosenberg, Albert B. Einstein

Research output: Contribution to journalArticlepeer-review

Abstract

From 61 to 92% of the total sialic acid of a variety of human lymphoid cell lines maintained in tissue culture is present on the cell surface as measured by its susceptibility to cleavage by Clostridium perjringens neuraminidase. These cells contain from 1.22 × 108 to 6.99 × 108 molecules of surface sialic acid per cell. In synchronized cultures synthesis of surface sialic acid occurs only during a limited time in the late G2 phase of the cell cycle. The amount and density of surface sialic acid vary considerably throughout the cell cycle.

Original languageEnglish (US)
Pages (from-to)466-473
Number of pages8
JournalJournal of Cell Biology
Volume53
Issue number2
DOIs
StatePublished - May 1 1972

ASJC Scopus subject areas

  • Cell Biology

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