Shrinkage prediction of seed-voxel brain connectivity using resting state fMRI

Haochang Shou, Ani Eloyan, Mary Beth Nebel, Amanda Mejia, James J. Pekar, Stewart Mostofsky, Brian Caffo, Martin A. Lindquist, Ciprian M. Crainiceanu

Research output: Contribution to journalComment/debatepeer-review

20 Scopus citations


Resting-state functional magnetic resonance imaging (rs-fMRI) is used to investigate synchronous activations in spatially distinct regions of the brain, which are thought to reflect functional systems supporting cognitive processes. Analyses are often performed using seed-based correlation analysis, allowing researchers to explore functional connectivity between data in a seed region and the rest of the brain. Using scan-rescan rs-fMRI data, we investigate how well the subject-specific seed-based correlation map from the second replication of the study can be predicted using data from the first replication. We show that one can dramatically improve prediction of subject-specific connectivity by borrowing strength from the group correlation map computed using all other subjects in the study. Even more surprisingly, we found that the group correlation map provided a better prediction of a subject's connectivity than the individual's own data. While further discussion and experimentation are required to understand how this can be used in practice, results indicate that shrinkage-based methods that borrow strength from the population mean should play a role in rs-fMRI data analysis.

Original languageEnglish (US)
Pages (from-to)938-944
Number of pages7
Issue numberP2
StatePublished - Nov 5 2014


  • Connectivity analysis
  • Empirical Bayes
  • Measurement error correction
  • Resting-state fMRI
  • Shrinkage estimator

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience


Dive into the research topics of 'Shrinkage prediction of seed-voxel brain connectivity using resting state fMRI'. Together they form a unique fingerprint.

Cite this