Should I stay or should I go? Eukaryotic translation initiation factors 1 and 1A control start codon recognition

Sarah F. Mitchell, Jon R. Lorsch

Research output: Contribution to journalShort survey

Abstract

Start codon selection is a key step in translation initiation as it sets the reading frame for decoding. Two eukaryotic initiation factors, eIF1 and eIF1A, are key actors in this process. Recent work has elucidated many details of the mechanisms these factors use to control start site selection. eIF1 prevents the irreversible GTP hydrolysis that commits the ribosome to initiation at a particular codon. eIF1A both promotes and inhibits commitment through the competing influences of its two unstructured termini. Both factors perform their tasks through a variety of interactions with other components of the initiation machinery, in many cases mediated by the unstructured regions of the two proteins.

Original languageEnglish (US)
Pages (from-to)27345-27349
Number of pages5
JournalJournal of Biological Chemistry
Volume283
Issue number41
DOIs
StatePublished - Oct 10 2008

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Should I stay or should I go? Eukaryotic translation initiation factors 1 and 1A control start codon recognition'. Together they form a unique fingerprint.

  • Cite this