Shorter telomeres may indicate dementia status in older individuals with Down syndrome

Edmund C. Jenkins, Lingling Ye, Hong Gu, Samantha A. Ni, Milen Velinov, Deborah Pang, Sharon J. Krinsky-McHale, Warren B. Zigman, Nicole Schupf, Wayne P Silverman

Research output: Contribution to journalArticle

Abstract

We have recently reported reduced telomere length in T lymphocytes of individuals with Down syndrome (DS) and dementia due to Alzheimer's disease (AD). We have now replicated and extended that study by finding that people with DS and mild cognitive impairment (MCI-DS) also have shorter telomeres than people with DS without MCI-DS. Additional new findings demonstrated that light intensity measurements from chromosome 21 alone, or in concert with chromosomes 1, 2, and 16, exhibited shorter telomeres in adults with DS and with either dementia or MCI-DS compared to aging per se. Chromosome 21 measurements appeared to be especially promising for use as a biomarker because there was no overlap in the distribution of light intensity measurement scores between demented or MCI-DS and non-demented participants. Given that early clinical symptoms of AD can be very difficult to recognize in this population of adults due to their pre-existing cognitive impairments, a valid biomarker would be of great value. Early detection is especially important because it would allow treatments to begin before significant damage to the central nervous system has occurred. Our findings suggest that it may be feasible to use telomere shortening as a biomarker for accurately inferring dementia status.

Original languageEnglish (US)
Pages (from-to)765-771
Number of pages7
JournalNeurobiology of Aging
Volume31
Issue number5
DOIs
StatePublished - May 2010

Fingerprint

Telomere
Down Syndrome
Dementia
Chromosomes, Human, Pair 21
Biomarkers
Alzheimer Disease
Telomere Shortening
Light
Chromosomes, Human, Pair 16
Chromosomes, Human, Pair 2
Chromosomes, Human, Pair 1
Central Nervous System
T-Lymphocytes
Population

Keywords

  • Dementia
  • Down syndrome
  • FISH
  • Individual chromosomes 21, 1, 2, 16
  • Interphase
  • Metaphase
  • Mild cognitive impairment
  • PNA
  • Telomere shortening

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Jenkins, E. C., Ye, L., Gu, H., Ni, S. A., Velinov, M., Pang, D., ... Silverman, W. P. (2010). Shorter telomeres may indicate dementia status in older individuals with Down syndrome. Neurobiology of Aging, 31(5), 765-771. https://doi.org/10.1016/j.neurobiolaging.2008.06.001

Shorter telomeres may indicate dementia status in older individuals with Down syndrome. / Jenkins, Edmund C.; Ye, Lingling; Gu, Hong; Ni, Samantha A.; Velinov, Milen; Pang, Deborah; Krinsky-McHale, Sharon J.; Zigman, Warren B.; Schupf, Nicole; Silverman, Wayne P.

In: Neurobiology of Aging, Vol. 31, No. 5, 05.2010, p. 765-771.

Research output: Contribution to journalArticle

Jenkins, EC, Ye, L, Gu, H, Ni, SA, Velinov, M, Pang, D, Krinsky-McHale, SJ, Zigman, WB, Schupf, N & Silverman, WP 2010, 'Shorter telomeres may indicate dementia status in older individuals with Down syndrome', Neurobiology of Aging, vol. 31, no. 5, pp. 765-771. https://doi.org/10.1016/j.neurobiolaging.2008.06.001
Jenkins, Edmund C. ; Ye, Lingling ; Gu, Hong ; Ni, Samantha A. ; Velinov, Milen ; Pang, Deborah ; Krinsky-McHale, Sharon J. ; Zigman, Warren B. ; Schupf, Nicole ; Silverman, Wayne P. / Shorter telomeres may indicate dementia status in older individuals with Down syndrome. In: Neurobiology of Aging. 2010 ; Vol. 31, No. 5. pp. 765-771.
@article{380dad71944e48608185c1de19896674,
title = "Shorter telomeres may indicate dementia status in older individuals with Down syndrome",
abstract = "We have recently reported reduced telomere length in T lymphocytes of individuals with Down syndrome (DS) and dementia due to Alzheimer's disease (AD). We have now replicated and extended that study by finding that people with DS and mild cognitive impairment (MCI-DS) also have shorter telomeres than people with DS without MCI-DS. Additional new findings demonstrated that light intensity measurements from chromosome 21 alone, or in concert with chromosomes 1, 2, and 16, exhibited shorter telomeres in adults with DS and with either dementia or MCI-DS compared to aging per se. Chromosome 21 measurements appeared to be especially promising for use as a biomarker because there was no overlap in the distribution of light intensity measurement scores between demented or MCI-DS and non-demented participants. Given that early clinical symptoms of AD can be very difficult to recognize in this population of adults due to their pre-existing cognitive impairments, a valid biomarker would be of great value. Early detection is especially important because it would allow treatments to begin before significant damage to the central nervous system has occurred. Our findings suggest that it may be feasible to use telomere shortening as a biomarker for accurately inferring dementia status.",
keywords = "Dementia, Down syndrome, FISH, Individual chromosomes 21, 1, 2, 16, Interphase, Metaphase, Mild cognitive impairment, PNA, Telomere shortening",
author = "Jenkins, {Edmund C.} and Lingling Ye and Hong Gu and Ni, {Samantha A.} and Milen Velinov and Deborah Pang and Krinsky-McHale, {Sharon J.} and Zigman, {Warren B.} and Nicole Schupf and Silverman, {Wayne P}",
year = "2010",
month = "5",
doi = "10.1016/j.neurobiolaging.2008.06.001",
language = "English (US)",
volume = "31",
pages = "765--771",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Shorter telomeres may indicate dementia status in older individuals with Down syndrome

AU - Jenkins, Edmund C.

AU - Ye, Lingling

AU - Gu, Hong

AU - Ni, Samantha A.

AU - Velinov, Milen

AU - Pang, Deborah

AU - Krinsky-McHale, Sharon J.

AU - Zigman, Warren B.

AU - Schupf, Nicole

AU - Silverman, Wayne P

PY - 2010/5

Y1 - 2010/5

N2 - We have recently reported reduced telomere length in T lymphocytes of individuals with Down syndrome (DS) and dementia due to Alzheimer's disease (AD). We have now replicated and extended that study by finding that people with DS and mild cognitive impairment (MCI-DS) also have shorter telomeres than people with DS without MCI-DS. Additional new findings demonstrated that light intensity measurements from chromosome 21 alone, or in concert with chromosomes 1, 2, and 16, exhibited shorter telomeres in adults with DS and with either dementia or MCI-DS compared to aging per se. Chromosome 21 measurements appeared to be especially promising for use as a biomarker because there was no overlap in the distribution of light intensity measurement scores between demented or MCI-DS and non-demented participants. Given that early clinical symptoms of AD can be very difficult to recognize in this population of adults due to their pre-existing cognitive impairments, a valid biomarker would be of great value. Early detection is especially important because it would allow treatments to begin before significant damage to the central nervous system has occurred. Our findings suggest that it may be feasible to use telomere shortening as a biomarker for accurately inferring dementia status.

AB - We have recently reported reduced telomere length in T lymphocytes of individuals with Down syndrome (DS) and dementia due to Alzheimer's disease (AD). We have now replicated and extended that study by finding that people with DS and mild cognitive impairment (MCI-DS) also have shorter telomeres than people with DS without MCI-DS. Additional new findings demonstrated that light intensity measurements from chromosome 21 alone, or in concert with chromosomes 1, 2, and 16, exhibited shorter telomeres in adults with DS and with either dementia or MCI-DS compared to aging per se. Chromosome 21 measurements appeared to be especially promising for use as a biomarker because there was no overlap in the distribution of light intensity measurement scores between demented or MCI-DS and non-demented participants. Given that early clinical symptoms of AD can be very difficult to recognize in this population of adults due to their pre-existing cognitive impairments, a valid biomarker would be of great value. Early detection is especially important because it would allow treatments to begin before significant damage to the central nervous system has occurred. Our findings suggest that it may be feasible to use telomere shortening as a biomarker for accurately inferring dementia status.

KW - Dementia

KW - Down syndrome

KW - FISH

KW - Individual chromosomes 21, 1, 2, 16

KW - Interphase

KW - Metaphase

KW - Mild cognitive impairment

KW - PNA

KW - Telomere shortening

UR - http://www.scopus.com/inward/record.url?scp=77950535729&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950535729&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2008.06.001

DO - 10.1016/j.neurobiolaging.2008.06.001

M3 - Article

C2 - 18635289

AN - SCOPUS:77950535729

VL - 31

SP - 765

EP - 771

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 5

ER -