Shorter telomeres may indicate dementia status in older individuals with Down syndrome

Edmund C. Jenkins, Lingling Ye, Hong Gu, Samantha A. Ni, Milen Velinov, Deborah Pang, Sharon J. Krinsky-McHale, Warren B. Zigman, Nicole Schupf, Wayne P. Silverman

Research output: Contribution to journalArticlepeer-review

Abstract

We have recently reported reduced telomere length in T lymphocytes of individuals with Down syndrome (DS) and dementia due to Alzheimer's disease (AD). We have now replicated and extended that study by finding that people with DS and mild cognitive impairment (MCI-DS) also have shorter telomeres than people with DS without MCI-DS. Additional new findings demonstrated that light intensity measurements from chromosome 21 alone, or in concert with chromosomes 1, 2, and 16, exhibited shorter telomeres in adults with DS and with either dementia or MCI-DS compared to aging per se. Chromosome 21 measurements appeared to be especially promising for use as a biomarker because there was no overlap in the distribution of light intensity measurement scores between demented or MCI-DS and non-demented participants. Given that early clinical symptoms of AD can be very difficult to recognize in this population of adults due to their pre-existing cognitive impairments, a valid biomarker would be of great value. Early detection is especially important because it would allow treatments to begin before significant damage to the central nervous system has occurred. Our findings suggest that it may be feasible to use telomere shortening as a biomarker for accurately inferring dementia status.

Original languageEnglish (US)
Pages (from-to)765-771
Number of pages7
JournalNeurobiology of Aging
Volume31
Issue number5
DOIs
StatePublished - May 1 2010

Keywords

  • Dementia
  • Down syndrome
  • FISH
  • Individual chromosomes 21, 1, 2, 16
  • Interphase
  • Metaphase
  • Mild cognitive impairment
  • PNA
  • Telomere shortening

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Fingerprint Dive into the research topics of 'Shorter telomeres may indicate dementia status in older individuals with Down syndrome'. Together they form a unique fingerprint.

Cite this