Shortening fraction: Its dependence on the starling mechanism

Alicia R. Mattiazzi, Horacio E. Cingolani, Hugo Montenegro

Research output: Contribution to journalReview articlepeer-review

Abstract

Summary: The influence of increasing muscle length (ML) from L0 to 15 to 20% of L0 and calcium concentration (Ca2+) from 1.34 to 10 mmol·litre-1 on shortening fraction has been analysed in cat papillary muscles. Shortening fraction was calculated by dividing the amount of shortening by the muscle length at which that shortening occurred. When the muscle shortened at constant total load, increasing muscle length from ≃ L0 to ≃ 15 % above L0, increased the shortening fraction from 0.2 ± 0.1 % to 7.1 ± 0.7% (P <0.01) and from 1.0 ± 0.5% to 12.2 ± 0.5% (P <0.01) at low and high (Ca2+) respectively. The highest shortening fraction values obtained (7 and 12%) correspond to calculated ejection fraction values of 20 and 32% respectively. At a given muscle length, increasing (Ca2+) significantly increased the shortening fraction (P <0.01). At constant afterload the shortening fraction increased from 3.5 ± 1% to 9.1 ± 1.9% when the muscle length changed from ≃ 5% to ≃ 20% above L0 and from 3,3 ± 1.6% to 14.3 ± 0.7% when the muscle was stretched from L0 to ≃ 20% above L0 at low and high calcium respectively. Shortening fraction values of 9 and 14% correspond to calculated ejection fraction values of 25 and 37% respectively. The results indicate that the shortening fraction is altered not only by changes in cardiac contractility but also by the Starling mechanism.

Original languageEnglish (US)
Pages (from-to)475-482
Number of pages8
JournalCardiovascular research
Volume15
Issue number8
DOIs
StatePublished - Aug 1981

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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