Short term treatment with leuprolide acetate is a successful adjunct to surgical therapy of leiomyomas of the uterus

C. C. Coddington, R. Brzyski, K. A. Hansen, D. R. Corley, K. McIntyre-Seltman, H. W. Jones

Research output: Contribution to journalArticle

Abstract

Gonadotropin releasing hormone analogs (GnRHa) have been used to induce a reduction in the size of leiomyomas of the uterus after three to six months of therapy. However, none of the studies have noted a significant decrease in size by the first month. Additionally, the results of two reports have suggested long term therapy with GnRHa induced significant aberrations of serum lipoproteins. To evaluate whether or not analog treatment for a short course (two months) would be efficacious, 27 patients with leiomyomas documented by examination of the pelvic area and vaginal ultrasound, who desired to preserve reproductive potential, had myomectomies two and one-half months after commencing depot leuprolide acetate therapy. The reduction in size of the uterus was 35 percent by the first month and the average reduction in the total volume was 44 percent after two months of treatment (474 ± 364 to 265 ± 173 milliliters; p

Original languageEnglish (US)
Pages (from-to)57-63
Number of pages7
JournalSurgery Gynecology and Obstetrics
Volume175
Issue number1
StatePublished - 1992
Externally publishedYes

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Leuprolide
Leiomyoma
Uterus
Gynecological Examination
Gonadotropin-Releasing Hormone
Uterine Myomectomy
Therapeutics
Lipoproteins
Serum

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Surgery

Cite this

Coddington, C. C., Brzyski, R., Hansen, K. A., Corley, D. R., McIntyre-Seltman, K., & Jones, H. W. (1992). Short term treatment with leuprolide acetate is a successful adjunct to surgical therapy of leiomyomas of the uterus. Surgery Gynecology and Obstetrics, 175(1), 57-63.

Short term treatment with leuprolide acetate is a successful adjunct to surgical therapy of leiomyomas of the uterus. / Coddington, C. C.; Brzyski, R.; Hansen, K. A.; Corley, D. R.; McIntyre-Seltman, K.; Jones, H. W.

In: Surgery Gynecology and Obstetrics, Vol. 175, No. 1, 1992, p. 57-63.

Research output: Contribution to journalArticle

Coddington, CC, Brzyski, R, Hansen, KA, Corley, DR, McIntyre-Seltman, K & Jones, HW 1992, 'Short term treatment with leuprolide acetate is a successful adjunct to surgical therapy of leiomyomas of the uterus', Surgery Gynecology and Obstetrics, vol. 175, no. 1, pp. 57-63.
Coddington CC, Brzyski R, Hansen KA, Corley DR, McIntyre-Seltman K, Jones HW. Short term treatment with leuprolide acetate is a successful adjunct to surgical therapy of leiomyomas of the uterus. Surgery Gynecology and Obstetrics. 1992;175(1):57-63.
Coddington, C. C. ; Brzyski, R. ; Hansen, K. A. ; Corley, D. R. ; McIntyre-Seltman, K. ; Jones, H. W. / Short term treatment with leuprolide acetate is a successful adjunct to surgical therapy of leiomyomas of the uterus. In: Surgery Gynecology and Obstetrics. 1992 ; Vol. 175, No. 1. pp. 57-63.
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