TY - JOUR
T1 - Short-Term Repeatability of Insulin Resistance Indexes in Older Adults
T2 - The Atherosclerosis Risk in Communities Study
AU - Poon, Anna K.
AU - Meyer, Michelle L.
AU - Reaven, Gerald
AU - Knowles, Joshua W.
AU - Selvin, Elizabeth
AU - Pankow, James S.
AU - Couper, David
AU - Loehr, Laura
AU - Heiss, Gerardo
N1 - Funding Information:
Financial Support: The ARIC Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute (NHLBI) contracts (HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, and HHSN268201100012C). M.L.M. was supported by the NHLBI T32 HL-007055 and UNC BIRCWH 5K12HD00144. E.S. was supported by National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases Grants K24DK106414 and R01DK089174.
Funding Information:
The ARIC Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute (NHLBI) contracts (HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, and HHSN268201100012C).M.L.M. was supported by the NHLBI T32 HL-007055 and UNC BIRCWH 5K12HD00144. E.S. was supported by National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases Grants K24DK106414 and R01DK089174.
Publisher Copyright:
© 2018 Endocrine Society.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Context The homeostatic model assessment of insulin resistance (HOMA-IR) and triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C) are insulin resistance indexes routinely used in clinical and population-based studies; however, their short-term repeatability is not well characterized. Objective To quantify the short-term repeatability of insulin resistance indexes and their analytes, consisting of fasting glucose and insulin for HOMA-IR and TG and HDL-C for TG/HDL-C. Design Prospective cohort study. Participants A total of 102 adults 68 to 88 years old without diabetes attended an initial examination and repeated examination (mean, 46 days; range, 28 to 102 days). Blood samples were collected, processed, shipped, and assayed following a standardized protocol. Main Outcome Measures Repeatability was quantified using the intraclass correlation coefficient (ICC) and within-person coefficient of variation (CV). Minimum detectable change (MDC 95) and minimum detectable difference with 95% confidence (MDD 95) were quantified. Results For HOMA-IR, insulin, and fasting glucose, the ICCs were 0.70, 0.68, and 0.70, respectively; their respective within-person CVs were 30.4%, 28.8%, and 5.6%. For TG/HDL-C, TG, and HDL-C, the ICCs were 0.80, 0.68, and 0.91, respectively; their respective within-person CVs were 23.0%, 20.6%, and 8.2%. The MDC 95 was 2.3 for HOMA-IR and 1.4 for TG/HDL-C. The MDD 95 for a sample of n = 100 was 0.8 for HOMA-IR and 0.6 for TG/HDL-C. Conclusions Short-term repeatability was fair to good for HOMA-IR and excellent for TG/HDL-C according to suggested benchmarks, reflecting the short-term variability of their analytes. These measurement properties can inform the use of these indexes in clinical and population-based studies.
AB - Context The homeostatic model assessment of insulin resistance (HOMA-IR) and triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C) are insulin resistance indexes routinely used in clinical and population-based studies; however, their short-term repeatability is not well characterized. Objective To quantify the short-term repeatability of insulin resistance indexes and their analytes, consisting of fasting glucose and insulin for HOMA-IR and TG and HDL-C for TG/HDL-C. Design Prospective cohort study. Participants A total of 102 adults 68 to 88 years old without diabetes attended an initial examination and repeated examination (mean, 46 days; range, 28 to 102 days). Blood samples were collected, processed, shipped, and assayed following a standardized protocol. Main Outcome Measures Repeatability was quantified using the intraclass correlation coefficient (ICC) and within-person coefficient of variation (CV). Minimum detectable change (MDC 95) and minimum detectable difference with 95% confidence (MDD 95) were quantified. Results For HOMA-IR, insulin, and fasting glucose, the ICCs were 0.70, 0.68, and 0.70, respectively; their respective within-person CVs were 30.4%, 28.8%, and 5.6%. For TG/HDL-C, TG, and HDL-C, the ICCs were 0.80, 0.68, and 0.91, respectively; their respective within-person CVs were 23.0%, 20.6%, and 8.2%. The MDC 95 was 2.3 for HOMA-IR and 1.4 for TG/HDL-C. The MDD 95 for a sample of n = 100 was 0.8 for HOMA-IR and 0.6 for TG/HDL-C. Conclusions Short-term repeatability was fair to good for HOMA-IR and excellent for TG/HDL-C according to suggested benchmarks, reflecting the short-term variability of their analytes. These measurement properties can inform the use of these indexes in clinical and population-based studies.
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U2 - 10.1210/jc.2017-02437
DO - 10.1210/jc.2017-02437
M3 - Article
C2 - 29618016
AN - SCOPUS:85048662006
SN - 0021-972X
VL - 103
SP - 2175
EP - 2181
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 6
ER -