Short-term repeatability of electrocardiographic Tpeak-Tend and QT intervals

Kapuaola S. Gellert, Pentti Rautaharju, Michelle L. Snyder, Eric A. Whitsel, Kunihiro Matsushita, Gerardo Heiss, Elsayed Z. Soliman

Research output: Contribution to journalArticlepeer-review

Abstract

Background The electrocardiographic (ECG) Tpeak-Tend interval (TpTe) is associated with arrhythmias and sudden cardiac death. TpTe offers a supplementary measure for the QT interval (QT), yet its repeatability has not been established. Purpose Evaluate short-term repeatability of TpTe and QT. Methods Four ECGs were obtained on sixty participants. The sources of variation, intra-class correlation coefficient (ICC) - an index of reproducibility - and minimal detectable change (MDC) were estimated for TpTe and QT. The impact of repeated measurements on repeatability was estimated for a hypothetical clinical trial designed to detect drug-induced prolongation of TpTe and QT. Results We used heart rate-adjusted QT [(QT)a] but TpTe in the study group was rate-invariant. The ICC [95% confidence interval (CI)] was 0.77 (0.69, 0.85) for TpTe, 0.75 (0.65, 0.85) for QT and 0.60 (0.47, 0.73) for (QT)a. The MDC (ms) was 21, 32 and 26 for TpTe, QT and (QT)a respectively. Conclusion TpTe has excellent repeatability supporting its use as a supplement to QT in observational and clinical studies.

Original languageEnglish (US)
Pages (from-to)356-361
Number of pages6
JournalJournal of Electrocardiology
Volume47
Issue number3
DOIs
StatePublished - 2014

Keywords

  • Electrocardiogram
  • QT
  • Repeat variation T
  • TpTe interval

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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