Short-term repeatability of electrocardiographic Tpeak-Tend and QT intervals

Kapuaola S. Gellert; Pentti Rautaharju; Michelle L. Snyder; Eric A. Whitsel; Kunihiro Matsushita; Gerardo Heiss; Elsayed Z. Soliman

doi:10.1016/j.jelectrocard.2014.03.002

Short-term repeatability of electrocardiographic Tpeak-Tend and QT intervals

Kapuaola S. Gellert, Pentti Rautaharju, Michelle L. Snyder, Eric A. Whitsel, Kunihiro Matsushita, Gerardo Heiss, Elsayed Z. Soliman

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Background The electrocardiographic (ECG) Tpeak-Tend interval (TpTe) is associated with arrhythmias and sudden cardiac death. TpTe offers a supplementary measure for the QT interval (QT), yet its repeatability has not been established. Purpose Evaluate short-term repeatability of TpTe and QT. Methods Four ECGs were obtained on sixty participants. The sources of variation, intra-class correlation coefficient (ICC) - an index of reproducibility - and minimal detectable change (MDC) were estimated for TpTe and QT. The impact of repeated measurements on repeatability was estimated for a hypothetical clinical trial designed to detect drug-induced prolongation of TpTe and QT. Results We used heart rate-adjusted QT [(QT)a] but TpTe in the study group was rate-invariant. The ICC [95% confidence interval (CI)] was 0.77 (0.69, 0.85) for TpTe, 0.75 (0.65, 0.85) for QT and 0.60 (0.47, 0.73) for (QT)a. The MDC (ms) was 21, 32 and 26 for TpTe, QT and (QT)a respectively. Conclusion TpTe has excellent repeatability supporting its use as a supplement to QT in observational and clinical studies.

Original language	English (US)
Pages (from-to)	356-361
Number of pages	6
Journal	Journal of Electrocardiology
Volume	47
Issue number	3
DOIs	https://doi.org/10.1016/j.jelectrocard.2014.03.002
State	Published - 2014

Keywords

Electrocardiogram
QT
Repeat variation T
TpTe interval

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.jelectrocard.2014.03.002

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@article{37b4f85496384aff929dfb86ee7a5b99,

title = "Short-term repeatability of electrocardiographic Tpeak-Tend and QT intervals",

abstract = "Background The electrocardiographic (ECG) Tpeak-Tend interval (TpTe) is associated with arrhythmias and sudden cardiac death. TpTe offers a supplementary measure for the QT interval (QT), yet its repeatability has not been established. Purpose Evaluate short-term repeatability of TpTe and QT. Methods Four ECGs were obtained on sixty participants. The sources of variation, intra-class correlation coefficient (ICC) - an index of reproducibility - and minimal detectable change (MDC) were estimated for TpTe and QT. The impact of repeated measurements on repeatability was estimated for a hypothetical clinical trial designed to detect drug-induced prolongation of TpTe and QT. Results We used heart rate-adjusted QT [(QT)a] but TpTe in the study group was rate-invariant. The ICC [95% confidence interval (CI)] was 0.77 (0.69, 0.85) for TpTe, 0.75 (0.65, 0.85) for QT and 0.60 (0.47, 0.73) for (QT)a. The MDC (ms) was 21, 32 and 26 for TpTe, QT and (QT)a respectively. Conclusion TpTe has excellent repeatability supporting its use as a supplement to QT in observational and clinical studies.",

keywords = "Electrocardiogram, QT, Repeat variation T, TpTe interval",

author = "Gellert, {Kapuaola S.} and Pentti Rautaharju and Snyder, {Michelle L.} and Whitsel, {Eric A.} and Kunihiro Matsushita and Gerardo Heiss and Soliman, {Elsayed Z.}",

note = "Funding Information: The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts ( HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, and HHSN268201100012C ). The authors thank the study participants for their important contribution. K.S.G. and M.L.S were supported by the National Heart, Lung, and Blood Institute T32 training grant HL-007055 .",

year = "2014",

doi = "10.1016/j.jelectrocard.2014.03.002",

language = "English (US)",

volume = "47",

pages = "356--361",

journal = "Journal of Electrocardiology",

issn = "0022-0736",

publisher = "Churchill Livingstone",

number = "3",

}

TY - JOUR

T1 - Short-term repeatability of electrocardiographic Tpeak-Tend and QT intervals

AU - Gellert, Kapuaola S.

AU - Rautaharju, Pentti

AU - Snyder, Michelle L.

AU - Whitsel, Eric A.

AU - Matsushita, Kunihiro

AU - Heiss, Gerardo

AU - Soliman, Elsayed Z.

N1 - Funding Information: The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts ( HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, and HHSN268201100012C ). The authors thank the study participants for their important contribution. K.S.G. and M.L.S were supported by the National Heart, Lung, and Blood Institute T32 training grant HL-007055 .

PY - 2014

Y1 - 2014

N2 - Background The electrocardiographic (ECG) Tpeak-Tend interval (TpTe) is associated with arrhythmias and sudden cardiac death. TpTe offers a supplementary measure for the QT interval (QT), yet its repeatability has not been established. Purpose Evaluate short-term repeatability of TpTe and QT. Methods Four ECGs were obtained on sixty participants. The sources of variation, intra-class correlation coefficient (ICC) - an index of reproducibility - and minimal detectable change (MDC) were estimated for TpTe and QT. The impact of repeated measurements on repeatability was estimated for a hypothetical clinical trial designed to detect drug-induced prolongation of TpTe and QT. Results We used heart rate-adjusted QT [(QT)a] but TpTe in the study group was rate-invariant. The ICC [95% confidence interval (CI)] was 0.77 (0.69, 0.85) for TpTe, 0.75 (0.65, 0.85) for QT and 0.60 (0.47, 0.73) for (QT)a. The MDC (ms) was 21, 32 and 26 for TpTe, QT and (QT)a respectively. Conclusion TpTe has excellent repeatability supporting its use as a supplement to QT in observational and clinical studies.

AB - Background The electrocardiographic (ECG) Tpeak-Tend interval (TpTe) is associated with arrhythmias and sudden cardiac death. TpTe offers a supplementary measure for the QT interval (QT), yet its repeatability has not been established. Purpose Evaluate short-term repeatability of TpTe and QT. Methods Four ECGs were obtained on sixty participants. The sources of variation, intra-class correlation coefficient (ICC) - an index of reproducibility - and minimal detectable change (MDC) were estimated for TpTe and QT. The impact of repeated measurements on repeatability was estimated for a hypothetical clinical trial designed to detect drug-induced prolongation of TpTe and QT. Results We used heart rate-adjusted QT [(QT)a] but TpTe in the study group was rate-invariant. The ICC [95% confidence interval (CI)] was 0.77 (0.69, 0.85) for TpTe, 0.75 (0.65, 0.85) for QT and 0.60 (0.47, 0.73) for (QT)a. The MDC (ms) was 21, 32 and 26 for TpTe, QT and (QT)a respectively. Conclusion TpTe has excellent repeatability supporting its use as a supplement to QT in observational and clinical studies.

KW - Electrocardiogram

KW - QT

KW - Repeat variation T

KW - TpTe interval

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DO - 10.1016/j.jelectrocard.2014.03.002

M3 - Article

C2 - 24792986

AN - SCOPUS:84899723303

SN - 0022-0736

VL - 47

SP - 356

EP - 361

JO - Journal of Electrocardiology

JF - Journal of Electrocardiology

IS - 3

ER -

Short-term repeatability of electrocardiographic Tpeak-Tend and QT intervals

Abstract

Keywords

ASJC Scopus subject areas

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