Short Telomeres Limit Tumor Progression In Vivo by Inducing Senescence

David M. Feldser, Carol W. Greider

Research output: Contribution to journalArticlepeer-review

Abstract

Telomere maintenance is critical for cancer progression. To examine mechanisms of tumor suppression induced by short telomeres, we crossed mice deficient for the RNA component of telomerase, mTR-/-, with Eμ-myc transgenic mice, an established model of Burkitt's lymphoma. Short telomeres suppressed tumor formation in Eμ-myc transgenic animals. Expression of Bcl2 blocked apoptosis in tumor cells, but surprisingly, mice with short telomeres were still resistant to tumor formation. Staining for markers of cellular senescence showed that pretumor cells induced senescence in response to short telomeres. Loss of p53 abrogated the short telomere response. This study provides in vivo evidence for the existence of a p53-mediated senescence mechanism in response to short telomeres that suppresses tumorigenesis.

Original languageEnglish (US)
Pages (from-to)461-469
Number of pages9
JournalCancer cell
Volume11
Issue number5
DOIs
StatePublished - May 8 2007

Keywords

  • CELLCYCLE

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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