Short report: Vaccination of pigs to control human neurocysticercosis

Armandoe Gonzalez, Charles G. Gauci, Dylan Barber, Robert H Gilman, Victor C W Tsang, Hector H. Garcia, Manuela Verastegui, Marshall W. Lightowlers

Research output: Contribution to journalArticle

Abstract

Taenia solium taeniasis/cysticercosis is a zoonotic disease complex in which the pig is an obligate intermediate host. The infection is widespread, particularly in the developing world, and neurocysticercosis is a major cause of human neurologic disease where the parasite is endemic. Despite easy availability, effective anti-parasitic drugs have not been deployed effectively to control disease transmission. We have investigated a vaccine strategy to prevent parasite infection of the pig intermediate host. Such a strategy would interrupt the parasite's life cycle and eliminate the source of infection for humans. Two recombinant antigens selected from the parasite oncosphere life cycle stage were tested in vaccination trials in pigs that were challenged orally with Taenia solium eggs. Both antigens were highly effective in protecting the pigs against infection with the parasite (98.6% and 99.9% protection, respectively). No viable cysts were found in eight pigs vaccinated with one of the antigens. A recombinant subunit vaccine based on oncosphere antigens has the potential to improve the available control measures for T. solium and thereby reduce or eliminate neurocysticercosis.

Original languageEnglish (US)
Pages (from-to)837-839
Number of pages3
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume72
Issue number6
StatePublished - Jun 2005

Fingerprint

Neurocysticercosis
Taenia solium
Vaccination
Swine
Antigens
Parasitic Diseases
Parasites
Life Cycle Stages
Taeniasis
Cysticercosis
Synthetic Vaccines
Subunit Vaccines
Zoonoses
Infection
Nervous System Diseases
Eggs
Cysts
Vaccines
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Gonzalez, A., Gauci, C. G., Barber, D., Gilman, R. H., Tsang, V. C. W., Garcia, H. H., ... Lightowlers, M. W. (2005). Short report: Vaccination of pigs to control human neurocysticercosis. American Journal of Tropical Medicine and Hygiene, 72(6), 837-839.

Short report : Vaccination of pigs to control human neurocysticercosis. / Gonzalez, Armandoe; Gauci, Charles G.; Barber, Dylan; Gilman, Robert H; Tsang, Victor C W; Garcia, Hector H.; Verastegui, Manuela; Lightowlers, Marshall W.

In: American Journal of Tropical Medicine and Hygiene, Vol. 72, No. 6, 06.2005, p. 837-839.

Research output: Contribution to journalArticle

Gonzalez, A, Gauci, CG, Barber, D, Gilman, RH, Tsang, VCW, Garcia, HH, Verastegui, M & Lightowlers, MW 2005, 'Short report: Vaccination of pigs to control human neurocysticercosis', American Journal of Tropical Medicine and Hygiene, vol. 72, no. 6, pp. 837-839.
Gonzalez, Armandoe ; Gauci, Charles G. ; Barber, Dylan ; Gilman, Robert H ; Tsang, Victor C W ; Garcia, Hector H. ; Verastegui, Manuela ; Lightowlers, Marshall W. / Short report : Vaccination of pigs to control human neurocysticercosis. In: American Journal of Tropical Medicine and Hygiene. 2005 ; Vol. 72, No. 6. pp. 837-839.
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