Short report: Rare Plasmodium falciparum merozoite surface protein 1 19-KDA (MSP-119) haplotypes identified in Mali using high-throughput genotyping methods

Shannon L. Takala, David L. Smith, Mahamadou A. Thera, Drissa Coulibaly, Ogobara K. Doumbo, Christopher V. Plowe

Research output: Contribution to journalArticle

Abstract

Genetic diversity in malaria vaccine antigens may compromise malaria vaccine efficacy, so it is important to understand this diversity and the processes that generate it. By applying new high-throughput genotyping methods to a large sample of infections from Mali (N = 1369), seven new 19-kDa merozoite surface protein 1 (MSP-119) haplotypes were identified. Herein we report the sequences of these new haplotypes and discuss their possible origins. Although they are present in < 1% of the samples examined, the existence of these rare haplotypes reveals a greater degree of diversity at this locus than previously reported and highlights the potential for Plasmodium to evolve under selective pressure from the immune system and from such interventions as vaccines and drugs.

Original languageEnglish (US)
Pages (from-to)855-859
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume76
Issue number5
StatePublished - May 1 2007

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ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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