Short report: Preliminary study of quinine pharmacokinetics in pregnant women with malaria-HIV co-infection

Kassoum Kayentao, Etienne A. Guirou, Ogobara K. Doumbo, Meera Venkatesan, Christopher V. Plowe, Teresa L. Parsons, Craig W. Hendrix, Myaing M. Nyunt

Research output: Contribution to journalArticlepeer-review

Abstract

Pregnant women bear the greatest burden of malaria-human immunodeficiency virus co-infection. Previous studies suggest that interaction with antiretroviral drugs may compromise antimalarial pharmacokinetics and treatment outcomes. We conducted a preliminary clinical study to assess quinine pharmacokinetics in Malian pregnant women with acute malaria who reported taking nevirapine-based antiretroviral therapy. Of seven women, six had stable concentrations of nevirapine in the plasma and one had none. Quinine concentrations were lower, and its metabolite 3-hydroxyquinine higher, in the six women with nevirapine than in the one without, and quinine concentrations were below the recommended therapeutic range in 50% of the women. This preliminary observation warrants further research to understand the impact of long-term antiretroviral therapy on the treatment of acute malaria.

Original languageEnglish (US)
Pages (from-to)530-534
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume90
Issue number3
DOIs
StatePublished - Mar 2014

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'Short report: Preliminary study of quinine pharmacokinetics in pregnant women with malaria-HIV co-infection'. Together they form a unique fingerprint.

Cite this