Short-lag spatial coherence beamforming of photoacoustic images for enhanced visualization of prostate brachytherapy seeds

Muyinatu A. Lediju Bell, Nathanael Kuo, Danny Y Song, Emad Boctor

Research output: Contribution to journalArticle

Abstract

Prostate brachytherapy, administered by implanting tiny radioactive seeds to treat prostate cancer, currently relies on transrectal ultrasound imaging for intraoperative visualization of the metallic seeds. Photoacoustic (PA) imaging has been suggested as a feasible alternative to ultrasound imaging due to its superior sensitivity to metal surrounded by tissue. However, PA images suffer from poor contrast when seeds are distant from the light source. We propose a transperineal light delivery method and investigate the application of a short-lag spatial coherence (SLSC) beamformer to enhance low-contrast photoacoustic signals that are distant from this type of light source. Performance is compared to a conventional delay-and-sum beamformer. A pure gelatin phantom was implanted with black ink-coated brachytherapy seeds and the mean contrast was improved by 3-25 dB with the SLSC beamformer for fiber-seed distances ranging 0.6-6.3 cm, when approximately 10% of the receive aperture elements were included in the short-lag sum. For fiber-seed distances greater than 3-4 cm, the mean contrast-to-noise ratio (CNR) was approximately doubled with the SLSC beamformer, while mean signal-to-noise ratios (SNR) were mostly similar with both beamformers. Lateral resolution was decreased by 2 mm, but improved with larger short-lag values at the expense of poorer CNR and SNR. Similar contrast and CNR improvements were achieved with an uncoated brachytherapy seed implanted in ex vivo tissue. Results indicate that the SLSC beamformer has potential to enhance the visualization of prostate brachytherapy seeds that are distant from the light source.

Original languageEnglish (US)
Pages (from-to)1964-1977
Number of pages14
JournalBiomedical Optics Express
Volume4
Issue number10
DOIs
StatePublished - 2013

Fingerprint

Brachytherapy
beamforming
seeds
Prostate
Seeds
time lag
Noise
Light
light sources
Signal-To-Noise Ratio
Ultrasonography
signal to noise ratios
Ink
fibers
gelatins
inks
Gelatin
Prostatic Neoplasms
delivery
apertures

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology

Cite this

Short-lag spatial coherence beamforming of photoacoustic images for enhanced visualization of prostate brachytherapy seeds. / Lediju Bell, Muyinatu A.; Kuo, Nathanael; Song, Danny Y; Boctor, Emad.

In: Biomedical Optics Express, Vol. 4, No. 10, 2013, p. 1964-1977.

Research output: Contribution to journalArticle

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