Background: C-terminal SPAK fragments are found in kidney medulla.
Results:Weidentified Dnpep as the protease responsible for SPAK cleavage, identified the sites of cleavage, and showed unusual preference for α helices.
Conclusion: C-terminal SPAK fragments originate from Dnpep-mediated proteolytic cleavage.
Significance: SPAK and its cleavage are significant for the regulation of renal Na+ reabsorption and control of blood pressure.
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology