TY - JOUR
T1 - Short communication
T2 - Simplified estimation of the long-term specificity of the BED assay to improve estimates of HIV incidence
AU - Hargrove, John
AU - Humphrey, Jean
PY - 2010/9/1
Y1 - 2010/9/1
N2 - The BED assay overestimates HIV incidence because a proportion, epsilon (ω), of chronically infected people test "false-recent." In the ZVITAMBO trial, 2796 postpartum women tested HIV positive at baseline and 5.1% tested "false-recent" by BED 12 months later, providing a population-based estimate of ω. At baseline, 7.2% (95% CI: 5.3-9.4) of positive women >30 years and 5.1% (95% CI: 3.5-7.2) of positive women with CD4 <200 cells/μl tested "recent" by BED. Thus, the proportions of BED-positive women in either of these subgroups (data that would be available in surveys measuring HIV and BED status) provided a reasonably tight upper bound for ω, which can be used to provide a lower bound for HIV incidence.
AB - The BED assay overestimates HIV incidence because a proportion, epsilon (ω), of chronically infected people test "false-recent." In the ZVITAMBO trial, 2796 postpartum women tested HIV positive at baseline and 5.1% tested "false-recent" by BED 12 months later, providing a population-based estimate of ω. At baseline, 7.2% (95% CI: 5.3-9.4) of positive women >30 years and 5.1% (95% CI: 3.5-7.2) of positive women with CD4 <200 cells/μl tested "recent" by BED. Thus, the proportions of BED-positive women in either of these subgroups (data that would be available in surveys measuring HIV and BED status) provided a reasonably tight upper bound for ω, which can be used to provide a lower bound for HIV incidence.
UR - http://www.scopus.com/inward/record.url?scp=77956352951&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956352951&partnerID=8YFLogxK
U2 - 10.1089/aid.2010.0009
DO - 10.1089/aid.2010.0009
M3 - Article
C2 - 20718627
AN - SCOPUS:77956352951
SN - 0889-2229
VL - 26
SP - 977
EP - 979
JO - AIDS research and human retroviruses
JF - AIDS research and human retroviruses
IS - 9
ER -