Short communication: Predicting adverse HIV-related outcomes in a resource-limited setting: Use of the inflammation marker α1- acid glycoprotein

Rahul Rawat, Jean H. Humphrey, Kuda Mutasa, Robert Ntozini, Rebecca J. Stoltzfus

Research output: Contribution to journalArticle

Abstract

Limited data exist on the use of acute-phase proteins as predictors of HIV-related outcomes. We examined the relationship between postpartum α1-acid glycoprotein (AGP) concentrations and HIV-related maternal mortality, mother-to-child transmission, and HIV-free survival among 643 Zimbabwean women. Elevated AGP was significantly associated with a 5.74-fold (p = 0.001) increased risk of maternal death, a 2.39-fold (p = 0.033) increased risk of postnatal transmission, and a marginally significant 1.85-fold (p = 0.087) increased risk of infant infection or death. In a resource-limited setting, AGP may be of utility as an inexpensive prognostic tool for HIV-infected individuals.

Original languageEnglish (US)
Pages (from-to)1171-1174
Number of pages4
JournalAIDS research and human retroviruses
Volume26
Issue number11
DOIs
StatePublished - Nov 1 2010

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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