Short communication: Limited influence of haptoglobin genotypes on severe malaria in Ghanaian children

Ulrich Bienzle, Teunis A. Eggelte, Lydia A. Adjei, Ekkehart Dietz, Stephan Ehrhardt, Jakob P. Cramer, Rowland N. Otchwemah, Frank P. Mockenhaupt

Research output: Contribution to journalArticlepeer-review

Abstract

Haptoglobin (Hp) polymorphisms in sub-Saharan Africa have been associated with an increased risk of severe malaria. However, available data are inconclusive. We examined the role of Hp polymorphisms in susceptibility to Plasmodium falciparum infection and to severe malaria in northern Ghana. Three groups each of 290 age and sex-matched children with severe malaria, children with asymptomatic P. falciparum infection and aparasitaemic healthy controls were studied. Hp typing was based on PCR. In all children, Hp1-1, Hp2-1, and Hp2-2 occurred in 32.4%, 54.1%, and 13.5%, respectively. The prevalence of the Hp genotypes did not differ significantly between groups. However, Hp2 alleles were least common in healthy children (0.379), more frequent in parasitaemic controls (0.402), and most common in severe malaria patients (0.434; χtrend2 = 3.7; P = 0.06). In matched pair analysis, no Hp genotype increased the risk of severe malaria. However, using Hp1-1 as a reference, children with Hp2-2 exhibited a slightly increased risk of severe malaria (odds ratio, 1.6; P = 0.04). These results indicate that Hp polymorhisms may have a rather limited influence on the development of severe malaria.

Original languageEnglish (US)
Pages (from-to)668-671
Number of pages4
JournalTropical Medicine and International Health
Volume10
Issue number7
DOIs
StatePublished - Jul 2005
Externally publishedYes

Keywords

  • Ghana
  • Haptoglobin polymorphisms
  • PCR
  • Severe malaria

ASJC Scopus subject areas

  • Parasitology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Short communication: Limited influence of haptoglobin genotypes on severe malaria in Ghanaian children'. Together they form a unique fingerprint.

Cite this