Short Communication: HIV Controller T Cells Effectively Inhibit Viral Replication in Alveolar Macrophages

Victoria E. Walker-Sperling, Christian Merlo, Robert W. Buckheit, Allison Lambert, Patrick Tarwater, Gregory D Kirk, M. Bradley Drummond, Joel N Blankson

Research output: Contribution to journalArticle

Abstract

Macrophages are targets of HIV-1 infection, and control of viral replication within these cells may be an important component of a T-cell-based vaccine. Although several studies have analyzed the ability of CD8+ T cells to inhibit viral replication in monocyte-derived macrophages, the effect of T cells on HIV-1-infected tissue macrophages is less clear. We demonstrate here that both CD4+ and CD8+ T-cell effectors from HIV controllers are capable of suppressing viral replication in bronchoalveolar lavage-derived alveolar macrophages. These findings have implications for HIV-1 vaccine and eradication strategies. Copyright Mary Ann Liebert, Inc 2016.

Original languageEnglish (US)
Pages (from-to)1097-1099
Number of pages3
JournalAIDS Research and Human Retroviruses
Volume32
Issue number10-11
DOIs
StatePublished - Nov 1 2016

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Alveolar Macrophages
HIV
T-Lymphocytes
HIV-1
Macrophages
AIDS Vaccines
Bronchoalveolar Lavage
Infection Control
HIV Infections
Vaccines

Keywords

  • alveolar macrophages
  • CD8 T cells
  • CTL
  • monocyte derived macrophages

ASJC Scopus subject areas

  • Immunology
  • Infectious Diseases
  • Virology

Cite this

Short Communication : HIV Controller T Cells Effectively Inhibit Viral Replication in Alveolar Macrophages. / Walker-Sperling, Victoria E.; Merlo, Christian; Buckheit, Robert W.; Lambert, Allison; Tarwater, Patrick; Kirk, Gregory D; Drummond, M. Bradley; Blankson, Joel N.

In: AIDS Research and Human Retroviruses, Vol. 32, No. 10-11, 01.11.2016, p. 1097-1099.

Research output: Contribution to journalArticle

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