Abstract
Macrophages are targets of HIV-1 infection, and control of viral replication within these cells may be an important component of a T-cell-based vaccine. Although several studies have analyzed the ability of CD8+ T cells to inhibit viral replication in monocyte-derived macrophages, the effect of T cells on HIV-1-infected tissue macrophages is less clear. We demonstrate here that both CD4+ and CD8+ T-cell effectors from HIV controllers are capable of suppressing viral replication in bronchoalveolar lavage-derived alveolar macrophages. These findings have implications for HIV-1 vaccine and eradication strategies. Copyright Mary Ann Liebert, Inc 2016.
Original language | English (US) |
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Pages (from-to) | 1097-1099 |
Number of pages | 3 |
Journal | AIDS research and human retroviruses |
Volume | 32 |
Issue number | 10-11 |
DOIs | |
State | Published - Nov 1 2016 |
Keywords
- CD8 T cells
- CTL
- alveolar macrophages
- monocyte derived macrophages
ASJC Scopus subject areas
- Immunology
- Virology
- Infectious Diseases