Short Communication: HIV Controller T Cells Effectively Inhibit Viral Replication in Alveolar Macrophages

Victoria E. Walker-Sperling, Christian Merlo, Robert W. Buckheit, Allison Lambert, Patrick Tarwater, Gregory D Kirk, M. Bradley Drummond, Joel N Blankson

Research output: Contribution to journalArticle

Abstract

Macrophages are targets of HIV-1 infection, and control of viral replication within these cells may be an important component of a T-cell-based vaccine. Although several studies have analyzed the ability of CD8+ T cells to inhibit viral replication in monocyte-derived macrophages, the effect of T cells on HIV-1-infected tissue macrophages is less clear. We demonstrate here that both CD4+ and CD8+ T-cell effectors from HIV controllers are capable of suppressing viral replication in bronchoalveolar lavage-derived alveolar macrophages. These findings have implications for HIV-1 vaccine and eradication strategies. Copyright Mary Ann Liebert, Inc 2016.

Original languageEnglish (US)
Pages (from-to)1097-1099
Number of pages3
JournalAIDS Research and Human Retroviruses
Volume32
Issue number10-11
DOIs
StatePublished - Nov 1 2016

Keywords

  • alveolar macrophages
  • CD8 T cells
  • CTL
  • monocyte derived macrophages

ASJC Scopus subject areas

  • Immunology
  • Infectious Diseases
  • Virology

Fingerprint Dive into the research topics of 'Short Communication: HIV Controller T Cells Effectively Inhibit Viral Replication in Alveolar Macrophages'. Together they form a unique fingerprint.

  • Cite this