Short Communication: False Recent Ratio of the Limiting-Antigen Avidity Assay and Viral Load Testing Algorithm among Cameroonians with Long-Term HIV Infection

Briana A. Lynch; Eshan U. Patel; Colleen R. Courtney; Aubin J. Nanfack; Jude Bimela; Xiaohong Wang; Issa Eid; Thomas C. Quinn; Oliver Laeyendecker; Phillipe N. Nyambi; Ralf Duerr; Andrew D. Redd

doi:10.1089/aid.2017.0084

Short Communication: False Recent Ratio of the Limiting-Antigen Avidity Assay and Viral Load Testing Algorithm among Cameroonians with Long-Term HIV Infection

Briana A. Lynch, Eshan U. Patel, Colleen R. Courtney, Aubin J. Nanfack, Jude Bimela, Xiaohong Wang, Issa Eid, Thomas C. Quinn, Oliver Laeyendecker, Phillipe N. Nyambi, Ralf Duerr, Andrew D. Redd

School of Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Current serological assays that are used for cross-sectional HIV incidence estimation have been shown to misclassify individuals with chronic infection. Limited information exists on the performance of cross-sectional incidence assays in Central Africa. HIV-positive individuals from Cameroon who were infected for at least 1 or 2 years were evaluated to determine the false recent ratio (FRR) of a two-assay algorithm, which includes the Limiting Antigen Avidity (LAg-Avidity) assay (normalized optical density units, ODn <1.5) and HIV viral load (>1000 copies/ml). The subject-level FRR was 5.3% (95% confidence interval [CI], 2.1-10.5) for individuals infected for ≥1 year and 3.9% (95% CI, 0.8-11.0) for individuals infected for ≥2 years. These data suggest that the LAg-Avidity plus viral load incidence algorithm may overestimate HIV incidence rates in Central Africa.

Original language	English (US)
Pages (from-to)	1114-1116
Number of pages	3
Journal	AIDS research and human retroviruses
Volume	33
Issue number	11
DOIs	https://doi.org/10.1089/aid.2017.0084
State	Published - Nov 2017

Keywords

HIV, cross-sectional incidence, Cameroon

ASJC Scopus subject areas

Immunology
Virology
Infectious Diseases

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10.1089/aid.2017.0084

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Lynch, B. A., Patel, E. U., Courtney, C. R., Nanfack, A. J., Bimela, J., Wang, X., Eid, I., Quinn, T. C., Laeyendecker, O., Nyambi, P. N., Duerr, R., & Redd, A. D. (2017). Short Communication: False Recent Ratio of the Limiting-Antigen Avidity Assay and Viral Load Testing Algorithm among Cameroonians with Long-Term HIV Infection. AIDS research and human retroviruses, 33(11), 1114-1116. https://doi.org/10.1089/aid.2017.0084

Short Communication: False Recent Ratio of the Limiting-Antigen Avidity Assay and Viral Load Testing Algorithm among Cameroonians with Long-Term HIV Infection. / Lynch, Briana A.; Patel, Eshan U.; Courtney, Colleen R. et al.
In: AIDS research and human retroviruses, Vol. 33, No. 11, 11.2017, p. 1114-1116.

Research output: Contribution to journal › Article › peer-review

Lynch, BA, Patel, EU, Courtney, CR, Nanfack, AJ, Bimela, J, Wang, X, Eid, I, Quinn, TC, Laeyendecker, O, Nyambi, PN, Duerr, R & Redd, AD 2017, 'Short Communication: False Recent Ratio of the Limiting-Antigen Avidity Assay and Viral Load Testing Algorithm among Cameroonians with Long-Term HIV Infection', AIDS research and human retroviruses, vol. 33, no. 11, pp. 1114-1116. https://doi.org/10.1089/aid.2017.0084

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abstract = "Current serological assays that are used for cross-sectional HIV incidence estimation have been shown to misclassify individuals with chronic infection. Limited information exists on the performance of cross-sectional incidence assays in Central Africa. HIV-positive individuals from Cameroon who were infected for at least 1 or 2 years were evaluated to determine the false recent ratio (FRR) of a two-assay algorithm, which includes the Limiting Antigen Avidity (LAg-Avidity) assay (normalized optical density units, ODn <1.5) and HIV viral load (>1000 copies/ml). The subject-level FRR was 5.3% (95% confidence interval [CI], 2.1-10.5) for individuals infected for ≥1 year and 3.9% (95% CI, 0.8-11.0) for individuals infected for ≥2 years. These data suggest that the LAg-Avidity plus viral load incidence algorithm may overestimate HIV incidence rates in Central Africa.",

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Short Communication: False Recent Ratio of the Limiting-Antigen Avidity Assay and Viral Load Testing Algorithm among Cameroonians with Long-Term HIV Infection

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