Short Communication: False Recent Ratio of the Limiting-Antigen Avidity Assay and Viral Load Testing Algorithm among Cameroonians with Long-Term HIV Infection

Briana A. Lynch, Eshan U. Patel, Colleen R. Courtney, Aubin J. Nanfack, Jude Bimela, Xiaohong Wang, Issa Eid, Thomas C. Quinn, Oliver Laeyendecker, Phillipe N. Nyambi, Ralf Duerr, Andrew D. Redd

Research output: Contribution to journalArticlepeer-review

Abstract

Current serological assays that are used for cross-sectional HIV incidence estimation have been shown to misclassify individuals with chronic infection. Limited information exists on the performance of cross-sectional incidence assays in Central Africa. HIV-positive individuals from Cameroon who were infected for at least 1 or 2 years were evaluated to determine the false recent ratio (FRR) of a two-assay algorithm, which includes the Limiting Antigen Avidity (LAg-Avidity) assay (normalized optical density units, ODn <1.5) and HIV viral load (>1000 copies/ml). The subject-level FRR was 5.3% (95% confidence interval [CI], 2.1-10.5) for individuals infected for ≥1 year and 3.9% (95% CI, 0.8-11.0) for individuals infected for ≥2 years. These data suggest that the LAg-Avidity plus viral load incidence algorithm may overestimate HIV incidence rates in Central Africa.

Original languageEnglish (US)
Pages (from-to)1114-1116
Number of pages3
JournalAIDS research and human retroviruses
Volume33
Issue number11
DOIs
StatePublished - Nov 2017

Keywords

  • HIV, cross-sectional incidence, Cameroon

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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