Short Communication: False Recent Ratio of the Limiting-Antigen Avidity Assay and Viral Load Testing Algorithm among Cameroonians with Long-Term HIV Infection

Briana A. Lynch, Eshan U. Patel, Colleen R. Courtney, Aubin J. Nanfack, Jude Bimela, Xiaohong Wang, Issa Eid, Thomas C Quinn, Oliver B. Laeyendecker, Phillipe N. Nyambi, Ralf Duerr, Andrew Redd

Research output: Contribution to journalArticle

Abstract

Current serological assays that are used for cross-sectional HIV incidence estimation have been shown to misclassify individuals with chronic infection. Limited information exists on the performance of cross-sectional incidence assays in Central Africa. HIV-positive individuals from Cameroon who were infected for at least 1 or 2 years were evaluated to determine the false recent ratio (FRR) of a two-assay algorithm, which includes the Limiting Antigen Avidity (LAg-Avidity) assay (normalized optical density units, ODn <1.5) and HIV viral load (>1000 copies/ml). The subject-level FRR was 5.3% (95% confidence interval [CI], 2.1-10.5) for individuals infected for ≥1 year and 3.9% (95% CI, 0.8-11.0) for individuals infected for ≥2 years. These data suggest that the LAg-Avidity plus viral load incidence algorithm may overestimate HIV incidence rates in Central Africa.

Original languageEnglish (US)
Pages (from-to)1114-1116
Number of pages3
JournalAIDS Research and Human Retroviruses
Volume33
Issue number11
DOIs
StatePublished - Nov 1 2017

Fingerprint

Viral Load
HIV Infections
Central Africa
Antigens
Incidence
HIV
Confidence Intervals
Cameroon
Infection

Keywords

  • HIV, cross-sectional incidence, Cameroon

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

Cite this

Short Communication : False Recent Ratio of the Limiting-Antigen Avidity Assay and Viral Load Testing Algorithm among Cameroonians with Long-Term HIV Infection. / Lynch, Briana A.; Patel, Eshan U.; Courtney, Colleen R.; Nanfack, Aubin J.; Bimela, Jude; Wang, Xiaohong; Eid, Issa; Quinn, Thomas C; Laeyendecker, Oliver B.; Nyambi, Phillipe N.; Duerr, Ralf; Redd, Andrew.

In: AIDS Research and Human Retroviruses, Vol. 33, No. 11, 01.11.2017, p. 1114-1116.

Research output: Contribution to journalArticle

Lynch, Briana A. ; Patel, Eshan U. ; Courtney, Colleen R. ; Nanfack, Aubin J. ; Bimela, Jude ; Wang, Xiaohong ; Eid, Issa ; Quinn, Thomas C ; Laeyendecker, Oliver B. ; Nyambi, Phillipe N. ; Duerr, Ralf ; Redd, Andrew. / Short Communication : False Recent Ratio of the Limiting-Antigen Avidity Assay and Viral Load Testing Algorithm among Cameroonians with Long-Term HIV Infection. In: AIDS Research and Human Retroviruses. 2017 ; Vol. 33, No. 11. pp. 1114-1116.
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