Short communication: Dynamic constraints on the second phase compartment of HIV-infected cells

Adam M. Spivak, S. Alireza Rabi, Moira A. McMahon, Liang Shan, Ahmad R. Sedaghat, Claus O. Wilke, Robert F. Siliciano

Research output: Contribution to journalArticlepeer-review

Abstract

The cells responsible for the second phase decay of HIV-1 viremia following the initiation of antiretroviral therapy have yet to be identified. A dynamic model that considers where drugs act in the virus life cycle places constraints on candidate cell types. In this regard, the rapid drop in viremia in patients starting regimens containing the integrase inhibitor raltegravir is of particular interest. We show here that the time delay between reverse transcription and integration is short in differentiated macrophages, making these cells poor candidates for the second phase compartment under the assumptions of standard models of viral dynamics.

Original languageEnglish (US)
Pages (from-to)759-761
Number of pages3
JournalAIDS research and human retroviruses
Volume27
Issue number7
DOIs
StatePublished - Jul 1 2011

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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