Short- and long-term risk of colorectal adenoma recurrence among whites and blacks

Adeyinka O. Laiyemo, Chyke Doubeni, Hassan Brim, Hassan Ashktorab, Robert E. Schoen, Samir Gupta, Aline Charabaty Pishvaian, Elaine Lanza, Duane T. Smoot, Elizabeth A Platz, Amanda J. Cross

Research output: Contribution to journalArticle

Abstract

Background: It is unclear whether the higher burden from colorectal cancer among blacks is due to an increased biological susceptibility. Objective: To determine whether non-Hispanic blacks (blacks) have a higher risk of adenoma recurrence than non-Hispanic whites (whites) after removal of colorectal adenoma. Design: Secondary analysis of the Polyp Prevention Trial (PPT) data. Setting: United States. Patients: Patients were 1668 self-identified whites and 153 blacks who completed the 4-year trial. Of these, 688 whites and 55 blacks enrolled in a posttrial, passive Polyp Prevention Trial Continued Follow-up Study (PPT-CFS) and underwent another colonoscopy. Main Outcome Measurements: Recurrence and location of the adenoma and advanced adenoma by race-ethnicity during PPT and cumulative recurrence over a mean follow-up of 8.3 years (range, 4.9-12.4 years) among PPT-CFS enrollees. Results: Blacks had similar risk of recurrence of adenoma (39.2% vs 39.4%; incidence risk ratio [RR] =.98; 95% CI,.80-1.20) and advanced adenoma (8.5% vs 6.4%; RR = 1.18; 95% CI,.68-2.05) as whites at the end of PPT. Recurrence risk did not differ by colon subsite. Among PPT-CFS enrollees, the cumulative recurrence rate over a maximal follow-up period of 12 years was similar for blacks and whites for adenoma (67.3% vs 67.0%; RR = 1.01; 95% CI,.84-1.21) and advanced adenoma (14.5% vs 16.9%; RR = 1.03; 95% CI,.60-1.79). Limitation: There were few blacks in the long-term follow-up study. Conclusions: Adenoma and advanced adenoma recurrence did not differ by race. Our study does not support more frequent surveillance colonoscopies for blacks with a personal history of adenoma as an intervention to reduce colorectal cancer disparity.

Original languageEnglish (US)
Pages (from-to)447-454
Number of pages8
JournalGastrointestinal Endoscopy
Volume77
Issue number3
DOIs
StatePublished - Mar 2013

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Adenoma
Recurrence
Polyps
Odds Ratio
Colonoscopy
Colorectal Neoplasms
hydroquinone
Colon
Incidence

ASJC Scopus subject areas

  • Gastroenterology
  • Radiology Nuclear Medicine and imaging

Cite this

Laiyemo, A. O., Doubeni, C., Brim, H., Ashktorab, H., Schoen, R. E., Gupta, S., ... Cross, A. J. (2013). Short- and long-term risk of colorectal adenoma recurrence among whites and blacks. Gastrointestinal Endoscopy, 77(3), 447-454. https://doi.org/10.1016/j.gie.2012.11.027

Short- and long-term risk of colorectal adenoma recurrence among whites and blacks. / Laiyemo, Adeyinka O.; Doubeni, Chyke; Brim, Hassan; Ashktorab, Hassan; Schoen, Robert E.; Gupta, Samir; Charabaty Pishvaian, Aline; Lanza, Elaine; Smoot, Duane T.; Platz, Elizabeth A; Cross, Amanda J.

In: Gastrointestinal Endoscopy, Vol. 77, No. 3, 03.2013, p. 447-454.

Research output: Contribution to journalArticle

Laiyemo, AO, Doubeni, C, Brim, H, Ashktorab, H, Schoen, RE, Gupta, S, Charabaty Pishvaian, A, Lanza, E, Smoot, DT, Platz, EA & Cross, AJ 2013, 'Short- and long-term risk of colorectal adenoma recurrence among whites and blacks', Gastrointestinal Endoscopy, vol. 77, no. 3, pp. 447-454. https://doi.org/10.1016/j.gie.2012.11.027
Laiyemo, Adeyinka O. ; Doubeni, Chyke ; Brim, Hassan ; Ashktorab, Hassan ; Schoen, Robert E. ; Gupta, Samir ; Charabaty Pishvaian, Aline ; Lanza, Elaine ; Smoot, Duane T. ; Platz, Elizabeth A ; Cross, Amanda J. / Short- and long-term risk of colorectal adenoma recurrence among whites and blacks. In: Gastrointestinal Endoscopy. 2013 ; Vol. 77, No. 3. pp. 447-454.
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abstract = "Background: It is unclear whether the higher burden from colorectal cancer among blacks is due to an increased biological susceptibility. Objective: To determine whether non-Hispanic blacks (blacks) have a higher risk of adenoma recurrence than non-Hispanic whites (whites) after removal of colorectal adenoma. Design: Secondary analysis of the Polyp Prevention Trial (PPT) data. Setting: United States. Patients: Patients were 1668 self-identified whites and 153 blacks who completed the 4-year trial. Of these, 688 whites and 55 blacks enrolled in a posttrial, passive Polyp Prevention Trial Continued Follow-up Study (PPT-CFS) and underwent another colonoscopy. Main Outcome Measurements: Recurrence and location of the adenoma and advanced adenoma by race-ethnicity during PPT and cumulative recurrence over a mean follow-up of 8.3 years (range, 4.9-12.4 years) among PPT-CFS enrollees. Results: Blacks had similar risk of recurrence of adenoma (39.2{\%} vs 39.4{\%}; incidence risk ratio [RR] =.98; 95{\%} CI,.80-1.20) and advanced adenoma (8.5{\%} vs 6.4{\%}; RR = 1.18; 95{\%} CI,.68-2.05) as whites at the end of PPT. Recurrence risk did not differ by colon subsite. Among PPT-CFS enrollees, the cumulative recurrence rate over a maximal follow-up period of 12 years was similar for blacks and whites for adenoma (67.3{\%} vs 67.0{\%}; RR = 1.01; 95{\%} CI,.84-1.21) and advanced adenoma (14.5{\%} vs 16.9{\%}; RR = 1.03; 95{\%} CI,.60-1.79). Limitation: There were few blacks in the long-term follow-up study. Conclusions: Adenoma and advanced adenoma recurrence did not differ by race. Our study does not support more frequent surveillance colonoscopies for blacks with a personal history of adenoma as an intervention to reduce colorectal cancer disparity.",
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T1 - Short- and long-term risk of colorectal adenoma recurrence among whites and blacks

AU - Laiyemo, Adeyinka O.

AU - Doubeni, Chyke

AU - Brim, Hassan

AU - Ashktorab, Hassan

AU - Schoen, Robert E.

AU - Gupta, Samir

AU - Charabaty Pishvaian, Aline

AU - Lanza, Elaine

AU - Smoot, Duane T.

AU - Platz, Elizabeth A

AU - Cross, Amanda J.

PY - 2013/3

Y1 - 2013/3

N2 - Background: It is unclear whether the higher burden from colorectal cancer among blacks is due to an increased biological susceptibility. Objective: To determine whether non-Hispanic blacks (blacks) have a higher risk of adenoma recurrence than non-Hispanic whites (whites) after removal of colorectal adenoma. Design: Secondary analysis of the Polyp Prevention Trial (PPT) data. Setting: United States. Patients: Patients were 1668 self-identified whites and 153 blacks who completed the 4-year trial. Of these, 688 whites and 55 blacks enrolled in a posttrial, passive Polyp Prevention Trial Continued Follow-up Study (PPT-CFS) and underwent another colonoscopy. Main Outcome Measurements: Recurrence and location of the adenoma and advanced adenoma by race-ethnicity during PPT and cumulative recurrence over a mean follow-up of 8.3 years (range, 4.9-12.4 years) among PPT-CFS enrollees. Results: Blacks had similar risk of recurrence of adenoma (39.2% vs 39.4%; incidence risk ratio [RR] =.98; 95% CI,.80-1.20) and advanced adenoma (8.5% vs 6.4%; RR = 1.18; 95% CI,.68-2.05) as whites at the end of PPT. Recurrence risk did not differ by colon subsite. Among PPT-CFS enrollees, the cumulative recurrence rate over a maximal follow-up period of 12 years was similar for blacks and whites for adenoma (67.3% vs 67.0%; RR = 1.01; 95% CI,.84-1.21) and advanced adenoma (14.5% vs 16.9%; RR = 1.03; 95% CI,.60-1.79). Limitation: There were few blacks in the long-term follow-up study. Conclusions: Adenoma and advanced adenoma recurrence did not differ by race. Our study does not support more frequent surveillance colonoscopies for blacks with a personal history of adenoma as an intervention to reduce colorectal cancer disparity.

AB - Background: It is unclear whether the higher burden from colorectal cancer among blacks is due to an increased biological susceptibility. Objective: To determine whether non-Hispanic blacks (blacks) have a higher risk of adenoma recurrence than non-Hispanic whites (whites) after removal of colorectal adenoma. Design: Secondary analysis of the Polyp Prevention Trial (PPT) data. Setting: United States. Patients: Patients were 1668 self-identified whites and 153 blacks who completed the 4-year trial. Of these, 688 whites and 55 blacks enrolled in a posttrial, passive Polyp Prevention Trial Continued Follow-up Study (PPT-CFS) and underwent another colonoscopy. Main Outcome Measurements: Recurrence and location of the adenoma and advanced adenoma by race-ethnicity during PPT and cumulative recurrence over a mean follow-up of 8.3 years (range, 4.9-12.4 years) among PPT-CFS enrollees. Results: Blacks had similar risk of recurrence of adenoma (39.2% vs 39.4%; incidence risk ratio [RR] =.98; 95% CI,.80-1.20) and advanced adenoma (8.5% vs 6.4%; RR = 1.18; 95% CI,.68-2.05) as whites at the end of PPT. Recurrence risk did not differ by colon subsite. Among PPT-CFS enrollees, the cumulative recurrence rate over a maximal follow-up period of 12 years was similar for blacks and whites for adenoma (67.3% vs 67.0%; RR = 1.01; 95% CI,.84-1.21) and advanced adenoma (14.5% vs 16.9%; RR = 1.03; 95% CI,.60-1.79). Limitation: There were few blacks in the long-term follow-up study. Conclusions: Adenoma and advanced adenoma recurrence did not differ by race. Our study does not support more frequent surveillance colonoscopies for blacks with a personal history of adenoma as an intervention to reduce colorectal cancer disparity.

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