Shining a New Light on RNA-Protein Interactions

Research output: Contribution to journalShort survey

Abstract

PAR-CLIP is a new technique for transcriptome-wide mapping of binding sites for RNA-binding proteins. In this technique, a photoactivatable nucleoside is incorporated into RNA and crosslinked to proteins in vivo with UV light. The crosslinked nucleoside causes a specific base change during processing for deep sequencing, allowing the precise identification of binding sites.

Original languageEnglish (US)
Pages (from-to)316-318
Number of pages3
JournalChemistry and Biology
Volume17
Issue number4
DOIs
StatePublished - Apr 23 2010

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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