Sexually transmitted infections, prostatitis, ejaculation frequency, and the odds of lower urinary tract symptoms

Siobhan Sutcliffe, Edward Giovannucci, Angelo Michael Demarzo, Walter C. Willett, Elizabeth A Platz

Research output: Contribution to journalArticle

Abstract

Early life sexual factors, including histories of sexually transmitted infections, young-onset prostatitis, and frequency of ejaculation, were investigated in relation to lower urinary tract symptoms (LUTS) in a large case-control study nested within the Health Professionals Follow-up Study. In 1992, study participants were asked to provide information on their histories of sexually transmitted infections, prostatitis, ejaculation frequency, surgery for an enlarged prostate, and LUTS. Information on prostate surgery and LUTS was updated every 2 years. LUTS cases were defined as men who reported surgery for an enlarged prostate or high-moderate to severe LUTS (≥15 points on the American Urological Association symptom index) on any study questionnaires (n = 4,608). Controls were men who did not report surgery for an enlarged prostate and who scored 0-7 points on the American Urological Association symptom index on all questionnaires (n = 17,967). History of gonorrhea (adjusted odds ratio = 1.76, 95% confidence interval: 1.43, 2.15) or young-onset prostatitis (adjusted OR = 1.55, 95% confidence interval: 1.22, 1.96) was positively associated with LUTS. No association was observed between ejaculation frequency in early adulthood and LUTS. These results suggest that early genitourinary infections may contribute to later development of LUTS, although confirmation in additional population settings is warranted.

Original languageEnglish (US)
Pages (from-to)898-906
Number of pages9
JournalAmerican Journal of Epidemiology
Volume162
Issue number9
DOIs
StatePublished - Nov 2005

Fingerprint

Prostatitis
Lower Urinary Tract Symptoms
Ejaculation
Sexually Transmitted Diseases
Prostate
Confidence Intervals
Gonorrhea
Case-Control Studies
Odds Ratio
Health
Infection

Keywords

  • Ejaculation
  • Gonorrhea
  • Prostatic hyperplasia
  • Prostatitis
  • Sexually transmitted diseases
  • Syphilis

ASJC Scopus subject areas

  • Epidemiology

Cite this

Sexually transmitted infections, prostatitis, ejaculation frequency, and the odds of lower urinary tract symptoms. / Sutcliffe, Siobhan; Giovannucci, Edward; Demarzo, Angelo Michael; Willett, Walter C.; Platz, Elizabeth A.

In: American Journal of Epidemiology, Vol. 162, No. 9, 11.2005, p. 898-906.

Research output: Contribution to journalArticle

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