TY - JOUR
T1 - Sexual transmission of hepatitis c virus among patients attending sexually transmitted diseases clinics in baltimore-an analysis of 309 sex partnerships
AU - Thomas, David L.
AU - Zenilman, Jonathan M.
AU - Alter, Harvey J.
AU - Shih, James W.
AU - Galai, Noya
AU - Carella, Anthony V.
AU - Quinn, Thomas C.
N1 - Funding Information:
Received 31 May 1994: revised 22 November 1994. Presented in part: 4th International Symposium on Hepatitis C. Tokyo. May 1993. Informed consent was obtained from study participants. This investigation was approved by the human subjects committee and subject recruitment was approved by the institutional review board ofthe Johns Hopkins Medical School. Financial support: National Institutes of Health (AI-16959. AI-29508). Reprints or correspondence: Dr. David Thomas. Division of Infectious Diseases. Johns Hopkins University School of Medicine. 1155 Ross Bldg.. no Rutland Ave.. Baltimore. MD 21205. The Journal of Infectious Diseases 1995;171:768-75 © t995 by The University of Chicago. All rights reserved. 0022-1899/95/7104-0002$01.00
PY - 1995/4
Y1 - 1995/4
N2 - The prevalence of antibodies to hepatitis C virus (anti-HCV), the behavioral and laboratory derived risk factors for anti-HCY, and the quantity and homology of HCY RNA were assessed among 1039 non-injection drug-using sexually transmitted disease (STD) patients representing 309 sex partnerships. Thirty-seven (7%) of 555 males and 19 (4%) of 484 females had anti-HCY. In logistic regression analyses, factors associated with anti-HCY included age (P <.001), greater numbers of lifetime sex partners (P, P =.023), human immunodeficiency virus infection (P<.001), Trichomonas infection (P <.001), cigarette smoking (P <.001), and male homosexual exposure (P =.012). Among couples, females whose sex partners were anti-HCY positive were 3.7 times more likely to have anti-HCY than females whose sex partners were anti-HCY negative (p =.039). The proportion of RNA homology between anti-HCY positive females and their male partners (94%) was higher than among randomly selected patients (82%). Sexual transmission of HCY may contribute to the high prevalence of anti-HCY reported in urban settings.
AB - The prevalence of antibodies to hepatitis C virus (anti-HCV), the behavioral and laboratory derived risk factors for anti-HCY, and the quantity and homology of HCY RNA were assessed among 1039 non-injection drug-using sexually transmitted disease (STD) patients representing 309 sex partnerships. Thirty-seven (7%) of 555 males and 19 (4%) of 484 females had anti-HCY. In logistic regression analyses, factors associated with anti-HCY included age (P <.001), greater numbers of lifetime sex partners (P, P =.023), human immunodeficiency virus infection (P<.001), Trichomonas infection (P <.001), cigarette smoking (P <.001), and male homosexual exposure (P =.012). Among couples, females whose sex partners were anti-HCY positive were 3.7 times more likely to have anti-HCY than females whose sex partners were anti-HCY negative (p =.039). The proportion of RNA homology between anti-HCY positive females and their male partners (94%) was higher than among randomly selected patients (82%). Sexual transmission of HCY may contribute to the high prevalence of anti-HCY reported in urban settings.
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U2 - 10.1093/infdis/171.4.768
DO - 10.1093/infdis/171.4.768
M3 - Article
C2 - 7535827
AN - SCOPUS:0028922668
SN - 0022-1899
VL - 171
SP - 768
EP - 775
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 4
ER -