Sexual transmission of hepatitis c virus among patients attending sexually transmitted diseases clinics in baltimore-an analysis of 309 sex partnerships

David L. Thomas, Jonathan M. Zenilman, Harvey J. Alter, James W. Shih, Noya Galai, Anthony V. Carella, Thomas C. Quinn

Research output: Contribution to journalArticle

Abstract

The prevalence of antibodies to hepatitis C virus (anti-HCV), the behavioral and laboratory derived risk factors for anti-HCY, and the quantity and homology of HCY RNA were assessed among 1039 non-injection drug-using sexually transmitted disease (STD) patients representing 309 sex partnerships. Thirty-seven (7%) of 555 males and 19 (4%) of 484 females had anti-HCY. In logistic regression analyses, factors associated with anti-HCY included age (P <.001), greater numbers of lifetime sex partners (P, P =.023), human immunodeficiency virus infection (P<.001), Trichomonas infection (P <.001), cigarette smoking (P <.001), and male homosexual exposure (P =.012). Among couples, females whose sex partners were anti-HCY positive were 3.7 times more likely to have anti-HCY than females whose sex partners were anti-HCY negative (p =.039). The proportion of RNA homology between anti-HCY positive females and their male partners (94%) was higher than among randomly selected patients (82%). Sexual transmission of HCY may contribute to the high prevalence of anti-HCY reported in urban settings.

Original languageEnglish (US)
Pages (from-to)768-775
Number of pages8
JournalJournal of Infectious Diseases
Volume171
Issue number4
DOIs
StatePublished - Apr 1995

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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