Sexual partner characteristics and incident rectal Neisseria gonorrhoeae and Chlamydia trachomatis infections among gay men and other men who have sex with men (MSM): A prospective cohort in Abuja and Lagos, Nigeria

Habib O. Ramadhani, Hongjie Liu, Rebecca G. Nowak, Trevor A. Crowell, Teclaire Ndomb, Charlotte A Gaydos, Sheila Peel, Nicaise Ndembi, Stefan Baral, Julie Ake, Man E. Charurat

Research output: Contribution to journalArticle

Abstract

Background STIs including Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) potentiate HIV acquisition and transmission especially among gay men and other men who have sex with men (MSM). We investigated the influence of sexual network composition on incident rectal NG and/or CT infections among Nigerian MSM. Methods TRUST/RV368 is a cohort of MSM recruited using respondent-driven sampling at trusted community centres in Abuja and Lagos, Nigeria. MSM respondents (egos) provided STI risk factors and demographic information for up to five of their most recent sexual partners (alters) within their sexual networks. Egos were tested for HIV, NG and CT every 3months. Log-binomial regression was used to assess associations between alter characteristics and incident NG and/or CT. Results Between March 2013 and October 2015, 492 MSM were longitudinally screened for STIs, of which 28.0% (n=138) were positive for incident rectal STI (61 NG only, 42 CT only and 35 NG and CT). Among egos, condom use was associated with STIs (half of the time vs never (adjusted risk ratio (aRR) 0.5; 95% CI 0.3 to 0.8), always/almost always vs never (aRR 0.7; 95% CI 0.5 to 1.0)). Incident STIs were associated with having a younger alter ≤19 versus 30years (aRR 0.6; 95% CI 0.4 to 1.0), HIV infection (aRR 1.5; 95% CI 1.1 to 2.0) and engaging in sex under the influence of alcohol (aRR 1.4 95% CI 1.1 to 1.7) among regular alters and age ≤19 versus 30years (aRR 0.3; 95% CI 0.2 to 0.6), HIV infection (aRR 1.4; 95% CI 1.1 to 1.8) and engaging in sex under the influence of alcohol (aRR 1.2 95% CI 1.0 to 1.4) among casual alters. Conclusions Given the centrality of sexual partner characteristics as risks for incident STIs among Nigerian MSM, there is a need to move beyond individual interventions and syndromic surveillance and get out there' in the STI management.

Original languageEnglish (US)
Pages (from-to)348-355
Number of pages8
JournalSexually Transmitted Infections
Volume93
Issue number5
DOIs
StatePublished - Aug 1 2017

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Chlamydia Infections
Neisseria gonorrhoeae
Sexual Partners
Chlamydia trachomatis
Nigeria
Sexually Transmitted Diseases
Odds Ratio
Ego
HIV Infections
Alcohols
HIV
Sexual Minorities
Condoms
Demography

Keywords

  • CHLAMYDiA TRACHOMATIS
  • GAY MEN
  • HOMOSEXUALITY
  • NEISSERIA GONORRHOEA
  • SEXUAL NETWORKS

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

Cite this

Sexual partner characteristics and incident rectal Neisseria gonorrhoeae and Chlamydia trachomatis infections among gay men and other men who have sex with men (MSM) : A prospective cohort in Abuja and Lagos, Nigeria. / Ramadhani, Habib O.; Liu, Hongjie; Nowak, Rebecca G.; Crowell, Trevor A.; Ndomb, Teclaire; Gaydos, Charlotte A; Peel, Sheila; Ndembi, Nicaise; Baral, Stefan; Ake, Julie; Charurat, Man E.

In: Sexually Transmitted Infections, Vol. 93, No. 5, 01.08.2017, p. 348-355.

Research output: Contribution to journalArticle

Ramadhani, Habib O. ; Liu, Hongjie ; Nowak, Rebecca G. ; Crowell, Trevor A. ; Ndomb, Teclaire ; Gaydos, Charlotte A ; Peel, Sheila ; Ndembi, Nicaise ; Baral, Stefan ; Ake, Julie ; Charurat, Man E. / Sexual partner characteristics and incident rectal Neisseria gonorrhoeae and Chlamydia trachomatis infections among gay men and other men who have sex with men (MSM) : A prospective cohort in Abuja and Lagos, Nigeria. In: Sexually Transmitted Infections. 2017 ; Vol. 93, No. 5. pp. 348-355.
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title = "Sexual partner characteristics and incident rectal Neisseria gonorrhoeae and Chlamydia trachomatis infections among gay men and other men who have sex with men (MSM): A prospective cohort in Abuja and Lagos, Nigeria",
abstract = "Background STIs including Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) potentiate HIV acquisition and transmission especially among gay men and other men who have sex with men (MSM). We investigated the influence of sexual network composition on incident rectal NG and/or CT infections among Nigerian MSM. Methods TRUST/RV368 is a cohort of MSM recruited using respondent-driven sampling at trusted community centres in Abuja and Lagos, Nigeria. MSM respondents (egos) provided STI risk factors and demographic information for up to five of their most recent sexual partners (alters) within their sexual networks. Egos were tested for HIV, NG and CT every 3months. Log-binomial regression was used to assess associations between alter characteristics and incident NG and/or CT. Results Between March 2013 and October 2015, 492 MSM were longitudinally screened for STIs, of which 28.0{\%} (n=138) were positive for incident rectal STI (61 NG only, 42 CT only and 35 NG and CT). Among egos, condom use was associated with STIs (half of the time vs never (adjusted risk ratio (aRR) 0.5; 95{\%} CI 0.3 to 0.8), always/almost always vs never (aRR 0.7; 95{\%} CI 0.5 to 1.0)). Incident STIs were associated with having a younger alter ≤19 versus 30years (aRR 0.6; 95{\%} CI 0.4 to 1.0), HIV infection (aRR 1.5; 95{\%} CI 1.1 to 2.0) and engaging in sex under the influence of alcohol (aRR 1.4 95{\%} CI 1.1 to 1.7) among regular alters and age ≤19 versus 30years (aRR 0.3; 95{\%} CI 0.2 to 0.6), HIV infection (aRR 1.4; 95{\%} CI 1.1 to 1.8) and engaging in sex under the influence of alcohol (aRR 1.2 95{\%} CI 1.0 to 1.4) among casual alters. Conclusions Given the centrality of sexual partner characteristics as risks for incident STIs among Nigerian MSM, there is a need to move beyond individual interventions and syndromic surveillance and get out there' in the STI management.",
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author = "Ramadhani, {Habib O.} and Hongjie Liu and Nowak, {Rebecca G.} and Crowell, {Trevor A.} and Teclaire Ndomb and Gaydos, {Charlotte A} and Sheila Peel and Nicaise Ndembi and Stefan Baral and Julie Ake and Charurat, {Man E.}",
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TY - JOUR

T1 - Sexual partner characteristics and incident rectal Neisseria gonorrhoeae and Chlamydia trachomatis infections among gay men and other men who have sex with men (MSM)

T2 - A prospective cohort in Abuja and Lagos, Nigeria

AU - Ramadhani, Habib O.

AU - Liu, Hongjie

AU - Nowak, Rebecca G.

AU - Crowell, Trevor A.

AU - Ndomb, Teclaire

AU - Gaydos, Charlotte A

AU - Peel, Sheila

AU - Ndembi, Nicaise

AU - Baral, Stefan

AU - Ake, Julie

AU - Charurat, Man E.

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Background STIs including Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) potentiate HIV acquisition and transmission especially among gay men and other men who have sex with men (MSM). We investigated the influence of sexual network composition on incident rectal NG and/or CT infections among Nigerian MSM. Methods TRUST/RV368 is a cohort of MSM recruited using respondent-driven sampling at trusted community centres in Abuja and Lagos, Nigeria. MSM respondents (egos) provided STI risk factors and demographic information for up to five of their most recent sexual partners (alters) within their sexual networks. Egos were tested for HIV, NG and CT every 3months. Log-binomial regression was used to assess associations between alter characteristics and incident NG and/or CT. Results Between March 2013 and October 2015, 492 MSM were longitudinally screened for STIs, of which 28.0% (n=138) were positive for incident rectal STI (61 NG only, 42 CT only and 35 NG and CT). Among egos, condom use was associated with STIs (half of the time vs never (adjusted risk ratio (aRR) 0.5; 95% CI 0.3 to 0.8), always/almost always vs never (aRR 0.7; 95% CI 0.5 to 1.0)). Incident STIs were associated with having a younger alter ≤19 versus 30years (aRR 0.6; 95% CI 0.4 to 1.0), HIV infection (aRR 1.5; 95% CI 1.1 to 2.0) and engaging in sex under the influence of alcohol (aRR 1.4 95% CI 1.1 to 1.7) among regular alters and age ≤19 versus 30years (aRR 0.3; 95% CI 0.2 to 0.6), HIV infection (aRR 1.4; 95% CI 1.1 to 1.8) and engaging in sex under the influence of alcohol (aRR 1.2 95% CI 1.0 to 1.4) among casual alters. Conclusions Given the centrality of sexual partner characteristics as risks for incident STIs among Nigerian MSM, there is a need to move beyond individual interventions and syndromic surveillance and get out there' in the STI management.

AB - Background STIs including Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) potentiate HIV acquisition and transmission especially among gay men and other men who have sex with men (MSM). We investigated the influence of sexual network composition on incident rectal NG and/or CT infections among Nigerian MSM. Methods TRUST/RV368 is a cohort of MSM recruited using respondent-driven sampling at trusted community centres in Abuja and Lagos, Nigeria. MSM respondents (egos) provided STI risk factors and demographic information for up to five of their most recent sexual partners (alters) within their sexual networks. Egos were tested for HIV, NG and CT every 3months. Log-binomial regression was used to assess associations between alter characteristics and incident NG and/or CT. Results Between March 2013 and October 2015, 492 MSM were longitudinally screened for STIs, of which 28.0% (n=138) were positive for incident rectal STI (61 NG only, 42 CT only and 35 NG and CT). Among egos, condom use was associated with STIs (half of the time vs never (adjusted risk ratio (aRR) 0.5; 95% CI 0.3 to 0.8), always/almost always vs never (aRR 0.7; 95% CI 0.5 to 1.0)). Incident STIs were associated with having a younger alter ≤19 versus 30years (aRR 0.6; 95% CI 0.4 to 1.0), HIV infection (aRR 1.5; 95% CI 1.1 to 2.0) and engaging in sex under the influence of alcohol (aRR 1.4 95% CI 1.1 to 1.7) among regular alters and age ≤19 versus 30years (aRR 0.3; 95% CI 0.2 to 0.6), HIV infection (aRR 1.4; 95% CI 1.1 to 1.8) and engaging in sex under the influence of alcohol (aRR 1.2 95% CI 1.0 to 1.4) among casual alters. Conclusions Given the centrality of sexual partner characteristics as risks for incident STIs among Nigerian MSM, there is a need to move beyond individual interventions and syndromic surveillance and get out there' in the STI management.

KW - CHLAMYDiA TRACHOMATIS

KW - GAY MEN

KW - HOMOSEXUALITY

KW - NEISSERIA GONORRHOEA

KW - SEXUAL NETWORKS

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