Sexual dimorphism in immune response genes as a function of puberty

Rebecca Lamason, Po Zhao, Rashmi Rawat, Adrian Davis, John Hall, Jae Jin Chae, Rajeev Agarwal, Phillip Cohen, Antony Rosen, Eric P. Hoffman, Kanneboyina Nagaraju

Research output: Contribution to journalArticlepeer-review


Background: Autoimmune diseases are more prevalent in females than in males, whereas males have higher mortality associated with infectious diseases. To increase our understanding of this sexual dimorphism in the immune system, we sought to identify and characterize inherent differences in immune response programs in the spleens of male and female mice before, during and after puberty. Results: After the onset of puberty, female mice showed a higher expression of adaptive immune response genes, while males had a higher expression of innate immune genes. This result suggested a requirement for sex hormones. Using in vivo and in vitro assays in normal and mutant mouse strains, we found that reverse signaling through FasL was directly influenced by estrogen, with downstream consequences of increased CD8+ T cell-derived B cell help (via cytokines) and enhanced immunoglobulin production. Conclusion: These results demonstrate that sexual dimorphism in innate and adaptive immune genes is dependent on puberty. This study also revealed that estrogen influences immunoglobulin levels in post-pubertal female mice via the Fas-FasL pathway.

Original languageEnglish (US)
Article number2
JournalBMC Immunology
StatePublished - Feb 22 2006

ASJC Scopus subject areas

  • Immunology


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