Sexual Behavior, Smoking, and HIV-1 Infection in Haitian Women

Neal A. Halsey, Jacqueline S. Coberly, Elizabeth Holt, Jeannine Coreil, Patricia Kissinger, Lawrence H. Moulton, Jean Robert Brutus, Reginald Boulos

Research output: Contribution to journalArticle

Abstract

Objective.—To determine whether a previously observed association between human immunodeficiency virus type 1 (HIV-1) infection and smoking in Haitian women could be explained by confounding high-risk behaviors. Design and Setting.—A nested case-control study at a primary care health clinic in Cité Soleil, Haiti. Participants.—Women who reported having smoked (n=89) and randomly selected nonsmokers (n = 329) who had participated in a survey 1 to 12 months earlier evaluating risk factors for HIV-1 infection. Main Outcome Measures.—Lifetime sexual practices, smoking, health beliefs and practices, and other factors potentially confounding the relationship between smoking and HIV-1 infection. Results.—Compared with nonsmokers, smokers reported higher rates of high-risk behaviors, including more lifetime sex partners (P<.001), being less likely to be married (P<.01), and being more likely to have visited folk healers (P<.01). No intravenous drug use was reported, and no significant differences were noted between smokers and nonsmokers in numbers of past surgical or dental procedures or injections. Adjustment for all factors associated with HIV-1 infection and smoking in regression analyses revealed an independent association between smoking and HIV-1 infection (odds ratio [OR], 3.4; 95% confidence interval [CI], 1.6 to 7.5). Other factors associated with HIV-1 infection included having more than two lifetime sex partners (OR, 3.4; 95% CI, 1.7 to 6.8) and lower socioeconomic status as reflected by a dirt floor in the home (OR, 8.6; 95% CI, 3.3 to 22.0). Conclusions.—Smoking is a marker for high-risk sexual behavior and is associated with an increased risk of HIV-1 infection in this population. The persistent association between smoking and HIV-1 infection after adjustment for all known risk factors suggests the possibility of a biologic effect of smoking that warrants further evaluation in other populations.

Original languageEnglish (US)
Pages (from-to)2062-2066
Number of pages5
JournalJAMA: The Journal of the American Medical Association
Volume267
Issue number15
DOIs
StatePublished - Apr 15 1992

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Sexual Behavior, Smoking, and HIV-1 Infection in Haitian Women'. Together they form a unique fingerprint.

  • Cite this