Sex steroids and risk of female genital tract infection

Patti Gravitt, Khalil Ghanem

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Sex steroids are central to regulation of the dual roles of the female reproductive tract: support of reproduction and protection against deleterious pathogen invasion. The mechanisms by which sex steroids orchestrate the balance between reproduction and protection against pathogenic microorganisms, however, are complex and poorly understood. Epidemiologic studies have revealed associations between sex steroids and diagnosis, shedding, transmission of sexually transmitted diseases and their clinical sequelae, as well as disruptions to the normal vaginal flora. Experimental approaches, including animal models, have provided some insight into the mechanism of these associations, though often with contradictory results. Inherent limitations in traditional approaches to understanding the physiology of sex steroid regulation of immunity in the female genital tract will require significant interdisciplinary collaboration.

Original languageEnglish (US)
Title of host publicationSex Hormones and Immunity to Infection
PublisherSpringer-Verlag Berlin Heidelberg
Pages257-279
Number of pages23
ISBN (Electronic)9783642021558
ISBN (Print)9783642021541
DOIs
StatePublished - Jan 1 2010

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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