Sex-specific development of cortical monoamine levels in mouse

Shelley Connell; Collins Karikari; Christine F. Hohmann

doi:10.1016/j.devbrainres.2004.03.008

Sex-specific development of cortical monoamine levels in mouse

Shelley Connell, Collins Karikari, Christine F. Hohmann

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Several mental health disorders exhibit sex differences in monoamine levels associated with dimorphic cortical ontogeny. Studies in rodents support the notion that monoamines can profoundly modulate morphogenesis. Here, we show significant sex and hemisphere differences in BALB/cByJ mice on postnatal day 3 for dopamine (DA) and serotonin (5-TH), supporting the notion that sex differences in early monoaminergic ontogeny may result in dimorphic cortical development. Such sex differences may also influence differential behavioral and/or clinical outcomes.

Original language	English (US)
Pages (from-to)	187-191
Number of pages	5
Journal	Developmental Brain Research
Volume	151
Issue number	1-2
DOIs	https://doi.org/10.1016/j.devbrainres.2004.03.008
State	Published - Jul 19 2004
Externally published	Yes

Keywords

Dimorphism
High performance liquid chromatography
Mental health
Monoamines
Mouse
Neural basis of behavior
Ontogeny

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

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10.1016/j.devbrainres.2004.03.008

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title = "Sex-specific development of cortical monoamine levels in mouse",

abstract = "Several mental health disorders exhibit sex differences in monoamine levels associated with dimorphic cortical ontogeny. Studies in rodents support the notion that monoamines can profoundly modulate morphogenesis. Here, we show significant sex and hemisphere differences in BALB/cByJ mice on postnatal day 3 for dopamine (DA) and serotonin (5-TH), supporting the notion that sex differences in early monoaminergic ontogeny may result in dimorphic cortical development. Such sex differences may also influence differential behavioral and/or clinical outcomes.",

keywords = "Dimorphism, High performance liquid chromatography, Mental health, Monoamines, Mouse, Neural basis of behavior, Ontogeny",

author = "Shelley Connell and Collins Karikari and Hohmann, {Christine F.}",

note = "Funding Information: The authors would like to thank Mrs. Carmen Redding for her assistance with sample collection and Dr. Irina Krasnova for helpful comments on the manuscript. The work was supported in part by grants 1SO6 GM51971, the National Association for Autism Research (NAAR) and 1 U54 MH066417-01A1.",

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doi = "10.1016/j.devbrainres.2004.03.008",

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T1 - Sex-specific development of cortical monoamine levels in mouse

AU - Connell, Shelley

AU - Karikari, Collins

AU - Hohmann, Christine F.

N1 - Funding Information: The authors would like to thank Mrs. Carmen Redding for her assistance with sample collection and Dr. Irina Krasnova for helpful comments on the manuscript. The work was supported in part by grants 1SO6 GM51971, the National Association for Autism Research (NAAR) and 1 U54 MH066417-01A1.

PY - 2004/7/19

Y1 - 2004/7/19

N2 - Several mental health disorders exhibit sex differences in monoamine levels associated with dimorphic cortical ontogeny. Studies in rodents support the notion that monoamines can profoundly modulate morphogenesis. Here, we show significant sex and hemisphere differences in BALB/cByJ mice on postnatal day 3 for dopamine (DA) and serotonin (5-TH), supporting the notion that sex differences in early monoaminergic ontogeny may result in dimorphic cortical development. Such sex differences may also influence differential behavioral and/or clinical outcomes.

AB - Several mental health disorders exhibit sex differences in monoamine levels associated with dimorphic cortical ontogeny. Studies in rodents support the notion that monoamines can profoundly modulate morphogenesis. Here, we show significant sex and hemisphere differences in BALB/cByJ mice on postnatal day 3 for dopamine (DA) and serotonin (5-TH), supporting the notion that sex differences in early monoaminergic ontogeny may result in dimorphic cortical development. Such sex differences may also influence differential behavioral and/or clinical outcomes.

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KW - High performance liquid chromatography

KW - Mental health

KW - Monoamines

KW - Mouse

KW - Neural basis of behavior

KW - Ontogeny

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Sex-specific development of cortical monoamine levels in mouse

Abstract

Keywords

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