Sex-specific development of cortical monoamine levels in mouse

Shelley Connell, Collins Karikari, Christine F. Hohmann

Research output: Contribution to journalArticle

Abstract

Several mental health disorders exhibit sex differences in monoamine levels associated with dimorphic cortical ontogeny. Studies in rodents support the notion that monoamines can profoundly modulate morphogenesis. Here, we show significant sex and hemisphere differences in BALB/cByJ mice on postnatal day 3 for dopamine (DA) and serotonin (5-TH), supporting the notion that sex differences in early monoaminergic ontogeny may result in dimorphic cortical development. Such sex differences may also influence differential behavioral and/or clinical outcomes.

Original languageEnglish (US)
Pages (from-to)187-191
Number of pages5
JournalDevelopmental Brain Research
Volume151
Issue number1-2
DOIs
StatePublished - Jul 19 2004
Externally publishedYes

Fingerprint

Sexual Development
Sex Characteristics
Morphogenesis
Mental Disorders
Rodentia
Dopamine
Serotonin
Mental Health

Keywords

  • Dimorphism
  • High performance liquid chromatography
  • Mental health
  • Monoamines
  • Mouse
  • Neural basis of behavior
  • Ontogeny

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Sex-specific development of cortical monoamine levels in mouse. / Connell, Shelley; Karikari, Collins; Hohmann, Christine F.

In: Developmental Brain Research, Vol. 151, No. 1-2, 19.07.2004, p. 187-191.

Research output: Contribution to journalArticle

Connell, Shelley ; Karikari, Collins ; Hohmann, Christine F. / Sex-specific development of cortical monoamine levels in mouse. In: Developmental Brain Research. 2004 ; Vol. 151, No. 1-2. pp. 187-191.
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