Sex related differences in metabolism of 14C acetate in response to steroid hormones by isolated rat hepatocytes

R. A. Cole; S. Margolis

doi:10.1055/s-0028-1093749

Sex related differences in metabolism of ¹⁴C acetate in response to steroid hormones by isolated rat hepatocytes

R. A. Cole, S. Margolis

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

No differences were found in the basal rate of lipid synthesis from ¹⁴C acetate in hepatocytes isolated from mature male and virgin female rats. Lipid biosynthesis was stimulated 22-43% in the female 60 min after the addition of gonadal steroids. This rapid response suggests that subtle differences exist in the enzyme profile controlling the pathways of lipid metabolism in male and female rats. These differences may have been determined genetically or acquired after a period of sex dependent hormonal stimulation beginning with puberty.

Original language	English (US)
Pages (from-to)	250-253
Number of pages	4
Journal	Hormone and Metabolic Research
Volume	7
Issue number	3
DOIs	https://doi.org/10.1055/s-0028-1093749
State	Published - 1975

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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10.1055/s-0028-1093749

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abstract = "No differences were found in the basal rate of lipid synthesis from 14C acetate in hepatocytes isolated from mature male and virgin female rats. Lipid biosynthesis was stimulated 22-43% in the female 60 min after the addition of gonadal steroids. This rapid response suggests that subtle differences exist in the enzyme profile controlling the pathways of lipid metabolism in male and female rats. These differences may have been determined genetically or acquired after a period of sex dependent hormonal stimulation beginning with puberty.",

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AB - No differences were found in the basal rate of lipid synthesis from 14C acetate in hepatocytes isolated from mature male and virgin female rats. Lipid biosynthesis was stimulated 22-43% in the female 60 min after the addition of gonadal steroids. This rapid response suggests that subtle differences exist in the enzyme profile controlling the pathways of lipid metabolism in male and female rats. These differences may have been determined genetically or acquired after a period of sex dependent hormonal stimulation beginning with puberty.

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Sex related differences in metabolism of ¹⁴C acetate in response to steroid hormones by isolated rat hepatocytes

Abstract

ASJC Scopus subject areas

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