Sex hormones, sex hormone binding globulin, and abdominal aortic calcification in women and men in the multi-ethnic study of atherosclerosis (MESA)

Erin Donnelly Michos, Dhananjay Vaidya, Susan M. Gapstur, Pamela J. Schreiner, Sherita Hill Golden, Nathan D. Wong, Michael H. Criqui, Pamela Ouyang

Research output: Contribution to journalArticle

Abstract

Background: Conflicting findings exist regarding the associations of sex hormones with subclinical atherosclerosis. Methods: This is a substudy from MESA of 881 postmenopausal women and 978 men who had both abdominal aortic calcification (AAC) quantified by computed tomography and sex hormone levels assessed [Testosterone (T), estradiol (E2), dehydroepiandrosterone (DHEA), and sex hormone binding globulin (SHBG)]. We examined the association of sex hormones with presence and extent of AAC. Results: For women, SHBG was inversely associated with both AAC presence [OR = 0.62, 95% CI 0.42-0.91 for 1 unit greater log(SHBG) level] and extent [0.29 lower log(AAC) for 1 unit greater log(SHBG) level, β = -0.29 (95% CI -0.57 to -0.006)] adjusting for age, race, hypertension, smoking, diabetes, BMI, physical activity, and other sex hormones. After further adjustment for total and HDL-cholesterol, SHBG was not associated with ACC presence or extent. In men, there was no association between SHBG and AAC. In both men and women, neither T, E2, nor DHEA was associated with AAC presence or extent. Conclusion: After adjustment for non-lipid cardiovascular risk factors, SHBG levels are inversely associated with both the presence and severity of AAC in women but not in men, which may be accounted for by HDL.

Original languageEnglish (US)
Pages (from-to)432-438
Number of pages7
JournalAtherosclerosis
Volume200
Issue number2
DOIs
StatePublished - Oct 2008

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Sex Hormone-Binding Globulin
Gonadal Steroid Hormones
Atherosclerosis
Dehydroepiandrosterone
HDL Cholesterol
Testosterone
Estradiol
Smoking
Tomography
Exercise
Hypertension

Keywords

  • Abdominal aortic calcification
  • Sex hormone binding globulin
  • Sex hormones
  • Subclinical atherosclerosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Sex hormones, sex hormone binding globulin, and abdominal aortic calcification in women and men in the multi-ethnic study of atherosclerosis (MESA). / Michos, Erin Donnelly; Vaidya, Dhananjay; Gapstur, Susan M.; Schreiner, Pamela J.; Golden, Sherita Hill; Wong, Nathan D.; Criqui, Michael H.; Ouyang, Pamela.

In: Atherosclerosis, Vol. 200, No. 2, 10.2008, p. 432-438.

Research output: Contribution to journalArticle

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AU - Vaidya, Dhananjay

AU - Gapstur, Susan M.

AU - Schreiner, Pamela J.

AU - Golden, Sherita Hill

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AB - Background: Conflicting findings exist regarding the associations of sex hormones with subclinical atherosclerosis. Methods: This is a substudy from MESA of 881 postmenopausal women and 978 men who had both abdominal aortic calcification (AAC) quantified by computed tomography and sex hormone levels assessed [Testosterone (T), estradiol (E2), dehydroepiandrosterone (DHEA), and sex hormone binding globulin (SHBG)]. We examined the association of sex hormones with presence and extent of AAC. Results: For women, SHBG was inversely associated with both AAC presence [OR = 0.62, 95% CI 0.42-0.91 for 1 unit greater log(SHBG) level] and extent [0.29 lower log(AAC) for 1 unit greater log(SHBG) level, β = -0.29 (95% CI -0.57 to -0.006)] adjusting for age, race, hypertension, smoking, diabetes, BMI, physical activity, and other sex hormones. After further adjustment for total and HDL-cholesterol, SHBG was not associated with ACC presence or extent. In men, there was no association between SHBG and AAC. In both men and women, neither T, E2, nor DHEA was associated with AAC presence or extent. Conclusion: After adjustment for non-lipid cardiovascular risk factors, SHBG levels are inversely associated with both the presence and severity of AAC in women but not in men, which may be accounted for by HDL.

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