Sex hormone changes during weight loss and maintenance in overweight and obese postmenopausal African-American and non-African-American women

Rachael Z. Stolzenberg-Solomon, Roni T. Falk, Frank Stanczyk, Robert N. Hoover, Lawrence Appel, Jamy D. Ard, Bryan C. Batch, Janelle Coughlin, Xu Han, Lillian F. Lien, Christina M. Pinkston, Laura P. Svetkey, Hormuzd A. Katki

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Abstract

Introduction: Changes in sex hormones with weight loss might have implications for breast cancer prevention but have not been examined extensively, particularly in African-American (AA) women.Methods: We conducted a prospective study of 278 overweight/obese postmenopausal women (38% AA) not taking hormone therapy within the Weight Loss Maintenance Trial. All participants lost at least 4 kg after a 6-month weight-loss phase and attempted to maintain weight loss during the subsequent 12 months. We evaluated the percentage changes in estrone, estradiol, free estradiol, testosterone, free testosterone, androstenedione, dehydroepiandrosterone sulfate and sex hormone-binding globulin (SHBG) using generalized estimating equations.Results: In all study phases, AA women had higher levels of estrogen and testosterone concentrations, independent of adiposity. On average, participants lost 7.7 kg during the weight-loss phase, and concentrations of estrone (-5.7%, P = 0.006), estradiol (-9.9%, P

Original languageEnglish (US)
Article numberR141
JournalBreast Cancer Research
Volume14
Issue number5
DOIs
StatePublished - Oct 31 2012

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Stolzenberg-Solomon, R. Z., Falk, R. T., Stanczyk, F., Hoover, R. N., Appel, L., Ard, J. D., Batch, B. C., Coughlin, J., Han, X., Lien, L. F., Pinkston, C. M., Svetkey, L. P., & Katki, H. A. (2012). Sex hormone changes during weight loss and maintenance in overweight and obese postmenopausal African-American and non-African-American women. Breast Cancer Research, 14(5), [R141]. https://doi.org/10.1186/bcr3346